Universität zu Köln

Siedek, Florian, Muehe, Anne M., Theruvath, Ashok J., Avedian, Raffi, Pribnow, Allison, Spunt, Sheri L., Liang, Tie, Farrell, Crystal and Daldrup-Link, Heike E. (2020). Comparison of ferumoxytol- and gadolinium chelate-enhanced MRI for assessment of sarcomas in children and adolescents. Eur. Radiol., 30 (3). S. 1790 - 1804. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objectives We compared the value of ferumoxytol (FMX)- and gadolinium (Gd)-enhanced MRI for assessment of sarcomas in paediatric/adolescent patients and hypothesised that tumour size and morphological features can be equally well assessed with both protocols. Methods We conducted a retrospective study of paediatric/adolescent patients with newly diagnosed bone or soft tissue sarcomas and both pre-treatment FMX- and Gd-MRI scans, which were maximal 4 weeks apart. Both protocols included T1- and T2-weighted sequences. One reader assessed tumour volumes, signal-to-noise ratios (SNR) of the primary tumour and adjacent tissues and contrast-to-noise ratios (CNR) of FMX- and Gd-MRI scans. Additionally, four readers scored FMX- and Gd-MRI scans according to 15 diagnostic parameters, using a Likert scale. The results were pooled across readers and compared between FMX- and Gd-MRI scans. Statistical methods included multivariate analyses with different models. Results Twenty-two patients met inclusion criteria (16 males, 6 females; mean age 15.3 +/- 5.0). Tumour volume was not significantly different on T1-LAVA (p = 0.721), T1-SE (p = 0.290) and T2-FSE (p = 0.609) sequences. Compared to Gd-MRI, FMX-MRI demonstrated significantly lower tumour SNR on T1-LAVA (p < 0.001), equal tumour SNR on T1-SE (p = 0.104) and T2-FSE (p = 0.305), significantly higher tumour-to-marrow CNR (p < 0.001) on T2-FSE as well as significantly higher tumour-to-liver (p = 0.021) and tumour-to-vessel (p = 0.003) CNR on T1-LAVA images. Peritumoural and marrow oedema enhanced significantly more on Gd-MRI compared to FMX-MRI (p < 0.001/p = 0.002, respectively). Tumour thrombi and neurovascular bundle involvement were assessed with a significantly higher confidence on FMX-MRI (both p < 0.001). Conclusions FMX-MRI provides equal assessment of the extent of bone and soft tissue sarcomas compared to Gd-MRI with improved tumour delineation and improved evaluation of neurovascular involvement and tumour thrombi. Therefore, FMX-MRI is a possible alternative to Gd-MRI for tumour staging in paediatric/adolescent sarcoma patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siedek, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Muehe, Anne M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Theruvath, Ashok J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Avedian, Raffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Pribnow, Allison UNSPECIFIED UNSPECIFIED UNSPECIFIED Spunt, Sheri L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liang, Tie UNSPECIFIED UNSPECIFIED UNSPECIFIED Farrell, Crystal UNSPECIFIED UNSPECIFIED UNSPECIFIED Daldrup-Link, Heike E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-343149
DOI:	10.1007/s00330-019-06569-y
Journal or Publication Title:	Eur. Radiol.
Volume:	30
Number:	3
Page Range:	S. 1790 - 1804
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUPERPARAMAGNETIC IRON-OXIDE; FOCAL LIVER-LESIONS; CONTRAST AGENTS; DEFICIENCY ANEMIA; GLOBUS-PALLIDUS; DENTATE NUCLEUS; BONE-MARROW; THERAPY; METASTASES; DIFFERENTIATION Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34314