Universität zu Köln

Javed, Faizan, Tamisier, Renaud, Pepin, Jean-Louis, Cowie, Martin R., Wegscheider, Karl, Angermann, Christiane, D'Ortho, Marie-Pia, Erdmann, Erland, Simonds, Anita K., Somers, Virend K., Teschler, Helmut, Levy, Patrick, Armitstead, Jeff and Woehrle, Holger (2020). Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis. Respirology, 25 (3). S. 305 - 312. HOBOKEN: WILEY. ISSN 1440-1843

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Abstract

Background and objective Increases in Cheyne-Stokes respiration (CSR) cycle length (CL), lung-to-periphery circulation time (LPCT) and time to peak flow (TTPF) may reflect impaired cardiac function. This retrospective analysis used an automatic algorithm to evaluate baseline CSR-related features and then determined whether these could be used to identify patients with systolic heart failure (HF) who experienced serious adverse events in the Treatment of Sleep-Disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure (SERVE-HF) substudy. Methods A total of 280 patients had overnight diagnostic polysomnography data available; an automated algorithm was applied to quantify CSR-related features. Results Median baseline CL, LPCT and TTPF were similar in the control (n = 152) and adaptive servo-ventilation (ASV, n = 156) groups. In both groups, CSR-related features were significantly longer in patients who did (n = 129) versus did not (n = 140) experience a primary endpoint event (all-cause death, life-saving cardiovascular intervention or unplanned hospitalization for worsening HF): CL, 61.1 versus 55.1 s (P = 0.002); LPCT, 36.5 versus 31.5 s (P < 0.001); TTPF, 15.20 versus 13.35 s (P < 0.001), respectively. This finding was independent of treatment allocation. Conclusion Patients with systolic HF and central sleep apnoea who experienced serious adverse events had longer CSR CL, LPCT and TTPF. Future studies should examine an independent role for CSR-related features to enable risk stratification in systolic HF.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Javed, Faizan UNSPECIFIED UNSPECIFIED UNSPECIFIED Tamisier, Renaud UNSPECIFIED UNSPECIFIED UNSPECIFIED Pepin, Jean-Louis UNSPECIFIED UNSPECIFIED UNSPECIFIED Cowie, Martin R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegscheider, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Angermann, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Ortho, Marie-Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Erdmann, Erland UNSPECIFIED UNSPECIFIED UNSPECIFIED Simonds, Anita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Somers, Virend K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Teschler, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Levy, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Armitstead, Jeff UNSPECIFIED UNSPECIFIED UNSPECIFIED Woehrle, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-343610
DOI:	10.1111/resp.13613
Journal or Publication Title:	Respirology
Volume:	25
Number:	3
Page Range:	S. 305 - 312
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1440-1843
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENTILATION; PREVALENCE; SECONDARY; PRESSURE; HF Multiple languages Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34361