Universität zu Köln

Quante, Anne S., Engel, Christoph, Kiechle, Marion, Schmutzler, Rita K. and Fischer, Christine (2020). Changes in risk calculation for the intensified surveillance programme of the German Consortium for Breast and Ovarian Cancer. Gynakologe, 53 (4). S. 259 - 265. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0393

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Abstract

Breast cancer is the most common cancer in women. About 30% of breast cancer patients have a family history of breast cancer and fulfil the inclusion criteria of the German Consortium (DK) Familial Breast and Ovarian Cancer. Women from these families in whom a mutation in one of the known cancer genes is detected are offered, among other things, the opportunity to participate in the intensified surveillance programme (INFP). However, if no mutation is found in a family, the decision to recommend intensified surveillance is based on the calculated risk. Preliminary results of the DK suggest that there is a need to improve the efficiency of the INFP and to continue the evaluation. So far, the risk calculation program Cyrillic has been used by the DK. However, as Cyrillic is outdated in terms of content and technology, DK will use the BOADICEA program in the future. BOADICEA was chosen for the following reasons: (i) it is scientifically up to date, (ii) it provides more accurate risk calculations taking into account new risk genes and (iii) it has been developed and validated using data from the DK and other populations. The change in the risk calculation procedure implies that different breast cancer risks are calculated for the women concerned. Therefore, new rules for risk classification have to be defined in order to improve the efficiency of the current INFP.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Quante, Anne S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiechle, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-343855
DOI:	10.1007/s00129-020-04572-9
Journal or Publication Title:	Gynakologe
Volume:	53
Number:	4
Page Range:	S. 259 - 265
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0393
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BOADICEA; PERFORMANCE; FAMILIES; MODEL Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34385