van Schie, Morten M. C. H., Kaczmarek, Alexander T., Tieves, Florian, Gomez de Santos, Patricia, Paul, Caroline E., Arends, Isabel W. C. E., Alcalde, Miguel, Schwarz, Guenter and Hollmann, Frank (2020). Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase-Catalysed In Situ Generation of H2O2. ChemCatChem, 12 (12). S. 3186 - 3190. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1867-3899

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Abstract

H2O2 can be accepted by several peroxygenases as a clean oxidant, able to supply both the necessary electrons and oxygen atom at the same time. The biocatalysts, in turn, are able to catalyse an array of interesting oxygen insertion reactions at enantio- and regio-selectivities hard to attain with classical chemical methods. The sensitivity of most peroxygenases towards H2O2, however, requires this oxidant to be generated in situ. Here, we suggest the application of (modified) sulfite oxidases to couple the oxidation of sulfites to the reduction of oxygen. This enables us to use calcium sulfite, an industrial waste product from scrubbing flue gases, as an electron donor to reduce oxygen. This will supply the required peroxide in a controlled manner and enables us to perform these challenging reactions at the expense of simple salts.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
van Schie, Morten M. C. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaczmarek, Alexander T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tieves, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomez de Santos, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paul, Caroline E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arends, Isabel W. C. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alcalde, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarz, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hollmann, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-344721
DOI: 10.1002/cctc.201902297
Journal or Publication Title: ChemCatChem
Volume: 12
Number: 12
Page Range: S. 3186 - 3190
Date: 2020
Publisher: WILEY-V C H VERLAG GMBH
Place of Publication: WEINHEIM
ISSN: 1867-3899
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VANADIUM CHLOROPEROXIDASE; OXIDATION; COMBINATION; PROVIDESMultiple languages
Chemistry, PhysicalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34472

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