Universität zu Köln

Schuetter, Maximilian and Graef, Martin (2020). Localized de novo phospholipid synthesis drives autophagosome biogenesis. Autophagy, 16 (4). S. 770 - 772. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1554-8635

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Abstract

During (macro)autophagy, cells form transient organelles, termed autophagosomes, to target a broad spectrum of substrates for degradation critical to cellular and organismal health. Driven by rapid membrane assembly, an initially small vesicle (phagophore) elongates into a large cup-shaped structure to engulf substrates within a few minutes in a double-membrane autophagosome. In particular, how autophagic membranes expand has been a longstanding question. Here, we summarize our recent work that delineates a pathway that drives phagophore expansion by localized de novo phospholipid synthesis. Specifically, we found that the conserved acyl-CoA synthetase Faa1 localizes to nucleated phagophores to locally activate fatty acids for de novo phospholipid synthesis in the neighboring ER. These newly synthesized phospholipids are then preferentially incorporated into autophagic membranes and drive the expansion of the phagophore into a functional autophagosome. In summary, our work uncovers molecular principles of how cells coordinate phospholipid synthesis and flux with autophagic membrane formation during autophagy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schuetter, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Graef, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-345220
DOI:	10.1080/15548627.2020.1725379
Journal or Publication Title:	Autophagy
Volume:	16
Number:	4
Page Range:	S. 770 - 772
Date:	2020
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1554-8635
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34522