Universität zu Köln

Pienar, Corina, Benninga, Marc A., Broekaert, Ilse J., Dolinsek, Jernej, Mas, Emmanuel ORCID: 0000-0001-5425-7352, Miele, Erasmo, Orel, Rok, Ribes-Koninckx, Carmen, Thomassen, Rut-Anne, Thomson, Mike, Tzivinikos, Christos and Thapar, Nikhil (2020). Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease. J. Pediatr. Gastroenterol. Nutr., 70 (2). S. 162 - 165. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4801

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Abstract

Acute diarrhoea is a leading cause of morbidity and mortality in the paediatric population. Racecadotril is an antisecretory drug recommended as an adjuvant antidiarrhoeal treatment. In the small bowel, the enzyme neutral endopeptidase (NEP) inhibits the action of enkephalins, which prevent water and electrolyte hypersecretion. By inhibiting NEP, racecadotril allows enkephalins to exhibit their antisecretory effects. Consequently, racecadotril reduces the secretion of water and electrolytes in the small intestine, without having an effect on intestinal motility. No serious adverse events related to racecadotril have been reported. Racecadotril has proven its efficacy as an adjuvant antidiarrhoeal drug with a good safety profile. Its addition to oral rehydration solution (ORS) appears clinically beneficial and potentially leads to health care savings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pienar, Corina UNSPECIFIED UNSPECIFIED UNSPECIFIED Benninga, Marc A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broekaert, Ilse J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolinsek, Jernej UNSPECIFIED UNSPECIFIED UNSPECIFIED Mas, Emmanuel UNSPECIFIED orcid.org/0000-0001-5425-7352 UNSPECIFIED Miele, Erasmo UNSPECIFIED UNSPECIFIED UNSPECIFIED Orel, Rok UNSPECIFIED UNSPECIFIED UNSPECIFIED Ribes-Koninckx, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomassen, Rut-Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomson, Mike UNSPECIFIED UNSPECIFIED UNSPECIFIED Tzivinikos, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED Thapar, Nikhil UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-345764
DOI:	10.1097/MPG.0000000000002574
Journal or Publication Title:	J. Pediatr. Gastroenterol. Nutr.
Volume:	70
Number:	2
Page Range:	S. 162 - 165
Date:	2020
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-4801
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE GASTROENTERITIS; NEUTRAL ENDOPEPTIDASE; ACUTE DIARRHEA; BUDGET IMPACT; COST-UTILITY; CHILDREN; INHIBITION; RATS Multiple languages Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34576