Bhargava, Ragini, Fischer, Matthias and O'Sullivan, Roderick J. (2020). Genome rearrangements associated with aberrant telomere maintenance. Curr. Opin. Genet. Dev., 60. S. 31 - 41. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0380
Full text not available from this repository.Abstract
There is unequivocal evidence that telomeres are crucial for cellular homeostasis and that telomere dysfunction can elicit genome instability and potentially initiate events that culminate in cancer. Mounting evidence points to telomeres having a crucial role in driving local and systemic structural rearrangements that drive cancer. These include the classical 'breakage-fusion-bridge' (BFB) cycles and more recently identified genome re-shaping events like kataegis and chromothripsis. In this brief review, we outline the established and most recent advances describing the roles that telomere dysfunction has in the origin of these catastrophic genome rearrangements. We discuss how local and systemic structural rearrangements enable telomere length maintenance, by either telomerase or the alternative lengthening of telomeres, that is essential to sustain cancer cell proliferation.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
|
||||||||||||||||
URN: | urn:nbn:de:hbz:38-345899 | ||||||||||||||||
DOI: | 10.1016/j.gde.2020.02.005 | ||||||||||||||||
Journal or Publication Title: | Curr. Opin. Genet. Dev. | ||||||||||||||||
Volume: | 60 | ||||||||||||||||
Page Range: | S. 31 - 41 | ||||||||||||||||
Date: | 2020 | ||||||||||||||||
Publisher: | CURRENT BIOLOGY LTD | ||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||
ISSN: | 1879-0380 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
Uncontrolled Keywords: |
|
||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/34589 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
View Item |