Universität zu Köln

Bhargava, Ragini, Fischer, Matthias and O'Sullivan, Roderick J. (2020). Genome rearrangements associated with aberrant telomere maintenance. Curr. Opin. Genet. Dev., 60. S. 31 - 41. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0380

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Abstract

There is unequivocal evidence that telomeres are crucial for cellular homeostasis and that telomere dysfunction can elicit genome instability and potentially initiate events that culminate in cancer. Mounting evidence points to telomeres having a crucial role in driving local and systemic structural rearrangements that drive cancer. These include the classical 'breakage-fusion-bridge' (BFB) cycles and more recently identified genome re-shaping events like kataegis and chromothripsis. In this brief review, we outline the established and most recent advances describing the roles that telomere dysfunction has in the origin of these catastrophic genome rearrangements. We discuss how local and systemic structural rearrangements enable telomere length maintenance, by either telomerase or the alternative lengthening of telomeres, that is essential to sustain cancer cell proliferation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bhargava, Ragini UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED O'Sullivan, Roderick J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-345899
DOI:	10.1016/j.gde.2020.02.005
Journal or Publication Title:	Curr. Opin. Genet. Dev.
Volume:	60
Page Range:	S. 31 - 41
Date:	2020
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0380
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TERT PROMOTER MUTATIONS; CANCER; CHROMOSOMES; CRISIS; CELLS; GENE; TRANSLOCATIONS; CHROMOTHRIPSIS; NEUROBLASTOMA; REPLICATION Multiple languages Cell Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34589