Universität zu Köln

Huebel, Kai, Ghielmini, Michele, Ladetto, Marco and Gopal, Ajay K. (2020). Controversies in the Treatment of Follicular Lymphoma. Hemasphere, 4 (1). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2572-9241

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Abstract

The overall prognosis of patients with follicular lymphoma has substantially improved over the last decades with a 10-year overall survival of around 80% for the majority of patients. However, for most patients follicular lymphoma it is still a relapsing and remitting disease. Furthermore, certain subsets of patients still have much shorter survival. Currently, there is no established standard how to treat high-risk follicular lymphoma. With advances in the understanding of the biology and pathogenesis of B cell malignancies, a plethora of new compounds have been investigated in FL. These compounds have the potential to increase efficacy if added to current regimens or even replace them. The implementation of these compounds in treatment algorithms is another unsolved issue. This overview highlights major controversies in the treatment of follicular lymphoma and discusses the most recent and relevant clinical trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Huebel, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghielmini, Michele UNSPECIFIED UNSPECIFIED UNSPECIFIED Ladetto, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Gopal, Ajay K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-345972
DOI:	10.1097/HS9.0000000000000317
Journal or Publication Title:	Hemasphere
Volume:	4
Number:	1
Date:	2020
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	2572-9241
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NON-HODGKIN-LYMPHOMA; B-CELL LYMPHOMA; CHOP PLUS RITUXIMAB; OPEN-LABEL; HIGH-RISK; PHASE-II; AUTOLOGOUS TRANSPLANTATION; OBINUTUZUMAB GA101; 1ST-LINE TREATMENT; ANTIBODY THERAPY Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34597