Universität zu Köln

Kasper, Philipp, Goebel, Heike and Michels, Guido (2020). mTOR-induced pneumonitis in a 72-year-old patient after heart transplantation. Dtsch. Med. Wochenschr., 145 (3). S. 189 - 195. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4413

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Abstract

History A 72-year-old heart transplant recipient presented to the hospital with progressive dyspnea. His immunosuppressive therapy was switched to the mTOR-inhibitor everolimus. A few months before, due to a progressive decline in renal function. Primarily, a community-acquired pneumonia was suspected and an empiric antibiotic therapy was initiated. Despite antimicrobial treatment, an acute respiratory distress syndrome developed and mechanical ventilation became necessary. Investigations During the following extensive diagnostic a transbronchial lung biopsy was performed and histological analysis revealed a drug induced lung injury. Diagnosis Based on the clinical and histological findings an everolimus induced pneumonitis was suspected. Treatment and course The drug was immediately discontinued and a high-dose steroid treatment was started, resulting in a significant improvement of respiratory function. Conclusion Everolimus-related interstitial pneumonitis represents a rare but important adverse effect of everolimus in immunosuppressed patients. Recognition of everolimus induced pneumonitis is of high clinical relevance and should be considered in all patients on everolimus presenting with respiratory symptoms of unknown origin.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kasper, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Goebel, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-347420
DOI:	10.1055/a-1008-7206
Journal or Publication Title:	Dtsch. Med. Wochenschr.
Volume:	145
Number:	3
Page Range:	S. 189 - 195
Date:	2020
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-4413
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERSTITIAL LUNG-DISEASE; EVEROLIMUS; INHIBITOR Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34742