Universität zu Köln

Biggs, Leah C., Kim, Christine S., Miroshnikova, Yekaterina A. and Wickstrom, Sara A. (2020). Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function. J. Invest. Dermatol., 140 (2). S. 284 - 291. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1747

Full text not available from this repository.

Abstract

Tissue shape emerges from the collective mechanical properties and behavior of individual cells and the ways by which they integrate into the surrounding tissue. Tissue architecture and its dynamic changes subsequently feed back to guide cell behavior. The skin is a dynamic, self-renewing barrier that is subjected to large-scale extrinsic mechanical forces throughout its lifetime. The ability to withstand this constant mechanical stress without compromising its integrity as a barrier requires compartment-specific structural specialization and the capability to sense and adapt to mechanical cues. This review discusses the unique mechanical properties of the skin and the importance of signals that arise from mechanical communication between cells and their environment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Biggs, Leah C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Christine S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Miroshnikova, Yekaterina A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickstrom, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-347731
DOI:	10.1016/j.jid.2019.06.137
Journal or Publication Title:	J. Invest. Dermatol.
Volume:	140
Number:	2
Page Range:	S. 284 - 291
Date:	2020
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-1747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SERUM RESPONSE FACTOR; TERMINAL DIFFERENTIATION; EPIDERMAL BARRIER; BASEMENT-MEMBRANE; FIBROBLAST HETEROGENEITY; ALPHA-6-BETA-4 INTEGRIN; EPIDERMOLYSIS-BULLOSA; TIGHT JUNCTIONS; CELL-ADHESION; ACTIN Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34773