Becker, Katja ORCID: 0000-0003-4858-5127, Banaschewski, Tobias ORCID: 0000-0003-4595-1144, Brandeis, Daniel, Dose, Christina, Hautmann, Christopher, Holtmann, Martin, Jans, Thomas, Jendreizik, Lea, Jenkner, Carolin, John, Katja, Ketter, Johanna, Millenet, Sabina, Pauli-Pott, Ursula, Renner, Tobias, Romanos, Marcel ORCID: 0000-0001-7628-8299, Treier, Anne-Katrin, von Wirth, Elena, Wermter, Anne-Kathrin and Doepfner, Manfred (2020). Individualised stepwise adaptive treatment for 3-6-year-old preschool children impaired by attention-deficit/hyperactivity disorder (ESCApreschool): study protocol of an adaptive intervention study including two randomised controlled trials within the consortium ESCAlife. Trials, 21 (1). LONDON: BMC. ISSN 1745-6215

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Abstract

Background Attention-deficit/hyperactivity disorder (ADHD) is a psychosocially impairing and cost-intensive mental disorder, with first symptoms occurring in early childhood. It can usually be diagnosed reliably at preschool age. Early detection of children with ADHD symptoms and an early, age-appropriate treatment are needed in order to reduce symptoms, prevent secondary problems and enable a better school start. Despite existing ADHD treatment research and guideline recommendations for the treatment of ADHD in preschool children, there is still a need to optimise individualised treatment strategies in order to improve outcomes. Therefore, the ESCApreschool study (Evidence-Based, Stepped Care of ADHD in Preschool Children aged 3 years and 0 months to 6 years and 11 months of age (3;0 to 6;11 years) addresses the treatment of 3-6-year-old preschool children with elevated ADHD symptoms within a large multicentre trial. The study aims to investigate the efficacy of an individualised stepwise-intensifying treatment programme. Methods The target sample size of ESCApreschool is 200 children (boys and girls) aged 3;0 to 6;11 years with an ADHD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) or a diagnosis of oppositional defiant disorder (ODD) plus additional substantial ADHD symptoms. The first step of the adaptive, stepped care design used in ESCApreschool consists of a telephone-assisted self-help (TASH) intervention for parents. Participants are randomised to either the TASH group or a waiting control group. The treatment in step 2 depends on the outcome of step 1: TASH responders without significant residual ADHD/ODD symptoms receive booster sessions of TASH. Partial or non-responders of step 1 are randomised again to either parent management and preschool teacher training or treatment as usual. Discussion The ESCApreschool trial aims to improve knowledge about individualised treatment strategies for preschool children with ADHD following an adaptive stepped care approach, and to provide a scientific basis for individualised medicine for preschool children with ADHD in routine clinical care.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Becker, KatjaUNSPECIFIEDorcid.org/0000-0003-4858-5127UNSPECIFIED
Banaschewski, TobiasUNSPECIFIEDorcid.org/0000-0003-4595-1144UNSPECIFIED
Brandeis, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dose, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hautmann, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holtmann, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jans, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jendreizik, LeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenkner, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ketter, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Millenet, SabinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauli-Pott, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renner, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romanos, MarcelUNSPECIFIEDorcid.org/0000-0001-7628-8299UNSPECIFIED
Treier, Anne-KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Wirth, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wermter, Anne-KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doepfner, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-349052
DOI: 10.1186/s13063-019-3872-8
Journal or Publication Title: Trials
Volume: 21
Number: 1
Date: 2020
Publisher: BMC
Place of Publication: LONDON
ISSN: 1745-6215
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; EXTERNALIZING PROBLEM BEHAVIOR; GUIDED SELF-HELP; DEFICIT HYPERACTIVITY DISORDER; INDICATED PREVENTION PROGRAM; GERMAN HEALTH; METHYLPHENIDATE TREATMENT; PARENTING INTERVENTIONS; MULTIMODAL TREATMENT; FAMILY INTERVENTIONMultiple languages
Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34905

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