Universität zu Köln

Gross, Angelina S. and Graef, Martin (2020). Mechanisms of Autophagy in Metabolic Stress Response. J. Mol. Biol., 432 (1). S. 28 - 53. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1089-8638

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Abstract

Autophagy is a highly conserved catabolic pathway critical for stress responses and the maintenance of cellular homeostasis. Defective autophagy contributes to the etiology of an increasing number of diseases including cancer, neurodegeneration, and diabetes. Cells have to integrate complex metabolic information in order to counteract metabolic challenges ranging from carbon, nitrogen, and phosphate to metal ion limitations. An unparalleled variety of cytoplasmic materials in size and nature can be transported into the lytic compartment for degradation and recycling by transient double-membrane compartments, termed autophagosomes, during macroautophagy. In this review, we will outline our current mechanistic understanding of how cells regulate the initiation of macroautophagy to target substrates nonselectively or selectively. With an emphasis on findings in the yeast system, we will describe the emerging principles underlying the regulation of autophagy substrate recognition, which critically shapes the scope of stress-adapted autophagy responses upon diverse metabolic challenges. (C) 2019 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gross, Angelina S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Graef, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-349246
DOI:	10.1016/j.jmb.2019.09.005
Journal or Publication Title:	J. Mol. Biol.
Volume:	432
Number:	1
Page Range:	S. 28 - 53
Date:	2020
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1089-8638
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOPLASMIC-RETICULUM TURNOVER; VACUOLE TARGETING PATHWAY; DEPENDENT PROTEIN-KINASE; ER-EXIT SITES; SELECTIVE AUTOPHAGY; SCAFFOLD PROTEIN; BINDING DOMAIN; ATG9 VESICLES; RAG GTPASES; EARLY STEPS Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34924