Universität zu Köln

Deshwal, Soni, Fiedler, Kai Uwe and Langer, Thomas (2020). Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity. In: Annual Review of Biochemistry, S. 501 - 529. PALO ALTO: ANNUAL REVIEWS. ISBN 978-0-8243-0889-6

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Abstract

Mitochondria are essential metabolic hubs that dynamically adapt to physiological demands. More than 40 proteases residing in different compartments of mitochondria, termed mitoproteases, preserve mitochondrial proteostasis and are emerging as central regulators of mitochondrial plasticity. These multifaceted enzymes limit the accumulation of short-lived, regulatory proteins within mitochondria, modulate the activity of mitochondrial proteins by protein processing, and mediate the degradation of damaged proteins. Various signaling cascades coordinate the activity of mitoproteases to preserve mitochondrial homeostasis and ensure cell survival. Loss of mitoproteases severely impairs the functional integrity of mitochondria, is associated with aging, and causes pleiotropic diseases. Understanding the dual function of mitoproteases as regulatory and quality control enzymes will help unravel the role of mitochondrial plasticity in aging and disease.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Deshwal, Soni UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiedler, Kai Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-349647
DOI:	10.1146/annurev-biochem-062917-012739
Title of Book:	Annual Review of Biochemistry
Series Name:	Annu. Rev. Biochem..
Volume:	89
Page Range:	S. 501 - 529
Date:	2020
Publisher:	ANNUAL REVIEWS
Place of Publication:	PALO ALTO
ISSN:	1545-4509
ISBN:	978-0-8243-0889-6
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language M-AAA PROTEASE; CYTOCHROME-C RELEASE; QUALITY-CONTROL; LON PROTEASE; PROCESSING PEPTIDASE; OPA1 ISOFORMS; PROTEOLYTIC CLEAVAGE; SPASTIC PARAPLEGIA; TUMOR-SUPPRESSOR; MEMBRANE-PROTEIN Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34964