Universität zu Köln

Javelle, Florian ORCID: 0000-0003-4240-2588, Lampit, Amit ORCID: 0000-0001-6522-8397, Bloch, Wilhelm, Haeussermann, Peter, Johnson, Sheri L. and Zimmer, Philipp (2020). Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis. Nutr. Rev., 78 (1). S. 77 - 89. CARY: OXFORD UNIV PRESS INC. ISSN 1753-4887

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Abstract

Context: Serotonergic dysfunction, including reduced central serotonin levels, is associated with different psychiatric syndromes, including depression. As a serotonin precursor, 5-hydroxytryptophan has long been used as a nonpharmacological treatment for depression. Objective: A systematic review and meta-analysis was conducted to determine the antidepressant effects of 5-hydroxytryptophan in depressed patients. Data sources: MEDLINE (via PubMed) and Google Scholar were searched from inception to May 2018. Data extraction: Thirteen investigations were included in the systematic review (using PRISMA guidelines), and 7 in the full meta-analysis (pre-registered on PROSPERO: CRD42018104415). Data analysis: Analyses revealed a depression remission rate of 0.65 (95% confidence interval [CI], 0.55-0.78; remission rate [k] = 13), and this was confirmed by the questionnaire results, which revealed a large Hedges' g (1.11; 95%CI, 0.53-1.69). Methodological variability (in treatment duration, type of depression studied, experimental design, 5-hydroxytryptophan dosage) contributes to heterogeneity in the results (I-2 = 76%, tau(2) = 0.379). In addition, the OHAT (Office of Health Assessment and Translation risk of bias rating) tool suggested that, on the whole, current studies are relatively weak (few include placebo groups). Conclusion: Further trials should overcome these limitations by using placebo-controlled studies that include patients with well-defined depression diagnoses, along with strong characterization of psychological and physiological patient characteristics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Javelle, Florian UNSPECIFIED orcid.org/0000-0003-4240-2588 UNSPECIFIED Lampit, Amit UNSPECIFIED orcid.org/0000-0001-6522-8397 UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeussermann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Johnson, Sheri L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-350107
DOI:	10.1093/nutrit/nuz039
Journal or Publication Title:	Nutr. Rev.
Volume:	78
Number:	1
Page Range:	S. 77 - 89
Date:	2020
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1753-4887
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHYSICAL-EXERCISE; L-5-HTP TREATMENT; TRYPTOPHAN; SEROTONIN; DEPLETION; IMPULSIVITY; SYMPTOMS; MOOD; L-5-HYDROXYTRYPTOPHAN; METABOLISM Multiple languages Nutrition & Dietetics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35010