Universität zu Köln

Zopfs, David, Lennartz, Simon, Zaeske, Charlotte, Merkt, Martin, Laukamp, Kai Roman, Reimer, Robert Peter, Maintz, David, Borggrefe, Jan ORCID: 0000-0003-2908-7560 and Hokamp, Nils Grosse (2020). Phantomless assessment of volumetric bone mineral density using virtual non-contrast images from spectral detector computed tomography. Br. J. Radiol., 93 (1109). LONDON: BRITISH INST RADIOLOGY. ISSN 1748-880X

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Abstract

Objective: To evaluate phantomless assessment of volumetric bone mineral density (vBMD) based on virtual non-contrast images of arterial (VNCa) and venous phase (VNCv) derived from spectral detector CT in comparison to true non-contrast (TNC) images and adjusted venous phase conventional images (CIV(adjusted)). Methods: 104 consecutive patients who underwent triphasic spectral detector CT between January 2018 and April 2019 were retrospectively included. TNC, VNCa, VNCv and venous phase images (CIV) were reconstructed. vBMD was obtained by two radiologists using an FDA/CE-cleared software. Average vBMD of the first three lumbar vertebrae was determined in each reconstruction; vBMD of CIV was adjusted for contrast enhancement as suggested earlier. Results: vBMD values obtained from CIV(adjusted) are comparable to vBMD values derived from TNC images (91.79 +/- 36.52 vs 90.16 +/- 41.71 mg/cm(3), p = 1.00); however, vBMD values derived from VNCa and VNCv (42.20 +/- 22.50 and 41.98 +/- 23.3 mg/cm(3) respectively) were significantly lower as compared to vBMD values from TNC and CIV(adjusted) (all p = 0.01). Conclusion: Spectral detector CT-derived virtual non-contrast images systematically underestimate vBMD and therefore should not be used without appropriate adjustments. Adjusted venous phase images provide reliable results and may be utilized for an opportunistic BMD screening in CT examinations. Advances in knowledge: Adjustments of venous phase images facilitate opportunistic assessment of vBMD, while spectral detector CT-derived VNC images systematically underestimate vBMD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zopfs, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Lennartz, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaeske, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkt, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Laukamp, Kai Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Reimer, Robert Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Borggrefe, Jan UNSPECIFIED orcid.org/0000-0003-2908-7560 UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-350938
DOI:	10.1259/bjr.20190992
Journal or Publication Title:	Br. J. Radiol.
Volume:	93
Number:	1109
Date:	2020
Publisher:	BRITISH INST RADIOLOGY
Place of Publication:	LONDON
ISSN:	1748-880X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DUAL-ENERGY CT; DIAGNOSTIC-ACCURACY; OSTEOPOROSIS; PREVALENCE; METASTASES; FRACTURES Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35093