Galldiks, Norbert ORCID: 0000-0002-2485-1796, Kocher, Martin, Ceccon, Garry, Werner, Jan-Michael, Brunn, Anna, Deckert, Martina, Pope, Whitney B., Soffietti, Riccardo, Le Rhun, Emilie, Weller, Michael ORCID: 0000-0002-1748-174X, Tonn, Joerg C., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2020). Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression. Neuro-Oncology, 22 (1). S. 17 - 31. CARY: OXFORD UNIV PRESS INC. ISSN 1523-5866

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Abstract

The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT-either alone (especially ICI) or in combination with radiotherapy-imaging findings on anatomical contrast-enhanced MRI can be unpredictable and highly variable, and are often difficult to interpret regarding treatment response and outcome. This review aims at summarizing the imaging challenges related to TT and ICI monotherapy as well as combined with radiotherapy in patients with brain metastases, and to give an overview on advanced imaging techniques which potentially overcome some of these imaging challenges. Currently, major evidence suggests that imaging parameters especially derived from amino acid PET, perfusion-/diffusion-weighted MRI, or MR spectroscopy may provide valuable additional information for the differentiation of treatment-induced changes from brain metastases recurrence and the evaluation of treatment response.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Galldiks, NorbertUNSPECIFIEDorcid.org/0000-0002-2485-1796UNSPECIFIED
Kocher, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ceccon, GarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werner, Jan-MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunn, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deckert, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pope, Whitney B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soffietti, RiccardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Rhun, EmilieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weller, MichaelUNSPECIFIEDorcid.org/0000-0002-1748-174XUNSPECIFIED
Tonn, Joerg C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Langen, Karl-JosefUNSPECIFIEDorcid.org/0000-0003-1101-5075UNSPECIFIED
URN: urn:nbn:de:hbz:38-351154
DOI: 10.1093/neuonc/noz147
Journal or Publication Title: Neuro-Oncology
Volume: 22
Number: 1
Page Range: S. 17 - 31
Date: 2020
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1523-5866
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
AMINO-ACID PET; POSITRON-EMISSION-TOMOGRAPHY; GAMMA-KNIFE RADIOSURGERY; RADIATION-INDUCED NECROSIS; IMMUNE CHECKPOINT THERAPY; STEREOTACTIC RADIOSURGERY; CEREBRAL METASTASES; PERFUSION-MRI; FDG-PET; MELANOMA PATIENTSMultiple languages
Oncology; Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/35115

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