Universität zu Köln

Wienemann, Hendrik, Broeckelmann, Paul J. and Adam, Matti ORCID: 0000-0002-6990-8135 (2020). Complete remission of Loeffler's endocarditis with Imatinib in a myeloid and lymphoid neoplasm associated with eosinophilia. Dtsch. Med. Wochenschr., 145 (1). S. 36 - 40. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4413

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Abstract

History and clinical findings A 53-year-old male presented with massive pruritus, whole-body exanthema, generalized muscle pain, and exercise dyspnoea NYHA II. Findings and Diagnosis Further hematologic examination lead to diagnosis of myeloid and lymphoid neoplasia with eosinophilia (MLN-EO) with FIPL1L1-PDGFRA fusion gene. An echocardiographic examination revealed a thrombus in the right ventricle. Magnetic resonance imaging (MRI) showed an extensive intracavitary thrombus extending from the apex to the right ventricular outflow tract. Therapy and course Oral anticoagulation with phenprocoumon and a targeted therapy with imatinib were initiated. Follow-up at 11- and 23-months revealed diminishing of the thrombus. Further follow-up did not show any complications. Conclusions In summary, Loeffler's endocarditis caused by a myeloid and lymphoid neoplasm associated with eosinophilia and abnormalities of FIP1L1-PDGFRA rearrangement could be treated successfully with oral anticoagulation therapy and the tyrosine-kinase inhibitor imatinib.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wienemann, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Broeckelmann, Paul J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Adam, Matti UNSPECIFIED orcid.org/0000-0002-6990-8135 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-352082
DOI:	10.1055/a-0977-8779
Journal or Publication Title:	Dtsch. Med. Wochenschr.
Volume:	145
Number:	1
Page Range:	S. 36 - 40
Date:	2020
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-4413
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DISORDERS; FUSION Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35208