Universität zu Köln

van Reij, R. R., I, Hoofwijk, D. M. N., Rutten, B. P. F., Weinhold, L., Leber, M., Joosten, E. A. J., Ramirez, A., van den Hoogen, N. J., Allegri, M., Bassoricci, E., Bettinelli, S., Bugada, D., Cedrati, V. L. E., Cappelleri, G., Compagnone, C., De Gregori, M., Fumagalli, R., Grimaldi, S., Mantelli, M., Molinaro, M. and Zorzetto, M. (2020). The association between genome-wide polymorphisms and chronic postoperative pain: a prospective observational study. Anaesthesia, 75. S. E111 - 10. HOBOKEN: WILEY. ISSN 1365-2044

Full text not available from this repository.

Abstract

Chronic postoperative pain is common and can have a negative impact on quality of life. Recent studies show that genetic risk factors are likely to play a role, although only gene-targeted analysis has been used to date. This is the first genome-wide association study to identify single-nucleotide polymorphisms associated with the development of chronic postoperative pain based on two independent cohorts. In a discovery cohort, 330 women scheduled for hysterectomy were genotyped. A case-control association analysis compared patients without chronic postoperative pain and the 34 who had severe chronic postoperative pain 3 months after surgery. No single-nucleotide polymorphisms reached genome-wide significance, but several showed suggestive associations with chronic postoperative pain (p < 1 x 10(-5)). Single-nucleotide polymorphisms with significance p NAV3 was significantly replicated with chronic postoperative pain in the replication cohort (p = 0.009). Meta-analysis revealed that two loci (IQGAP1 and CRTC3) were significantly associated with chronic postoperative pain at 3 months (IQGAP1 p = 3.93 x 10(-6) beta = 2.3863, CRTC3 p = 2.26 x 10(-6), beta = 2.4209). The present genome-wide association study provides initial evidence for genetic risk factors of chronic postoperative pain and supports follow-up studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Reij, R. R., I UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoofwijk, D. M. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rutten, B. P. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinhold, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leber, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Joosten, E. A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Hoogen, N. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Allegri, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bassoricci, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bettinelli, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bugada, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cedrati, V. L. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cappelleri, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Compagnone, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED De Gregori, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fumagalli, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimaldi, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mantelli, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Molinaro, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zorzetto, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-352353
DOI:	10.1111/anae.14832
Journal or Publication Title:	Anaesthesia
Volume:	75
Page Range:	S. E111 - 10
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2044
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC POSTSURGICAL PAIN; NERVOUS-SYSTEM; RISK-FACTORS; PREVALENCE; EXPRESSION; IMPUTATION; DISEASES; SURGERY; GENES; LOCI Multiple languages Anesthesiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35235