Tröder, Simon E. ORCID: 0000-0003-1156-2976 and Zevnik, Branko ORCID: 0000-0001-7845-9522 (2021). History of genome editing: From meganucleases to CRISPR. Laboratory Animals. ISSN 1758-1117
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Abstract
CRISPR-mediated genome editing has undoubtedly revolutionized genetic engineering of animals. With the ability for virtually unlimited modification of almost any genome it is easy to forget which amazing discoveries paved the way for this groundbreaking technology. Here, we summarize the history of genome editing platforms, starting from enhanced integration of foreign DNA by meganuclease-mediated double strand breaks to CRISPR/Cas9, the leading technology to date, and its re-engineered variants.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-368221 | ||||||||||||
DOI: | 10.1177/0023677221994613 | ||||||||||||
Journal or Publication Title: | Laboratory Animals | ||||||||||||
Date: | 23 February 2021 | ||||||||||||
ISSN: | 1758-1117 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Faculty of Medicine | ||||||||||||
Divisions: | CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases | ||||||||||||
Subjects: | Life sciences | ||||||||||||
Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/36822 |
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