Universität zu Köln

Lam, Max, Rashid, Nur Amirah Abdul, Lee, Sara-Ann, Lim, Jeanette, Foussias, George, Fervaha, Gagan, Ruhrman, Stephan, Remington, Gary and Lee, Jimmy ORCID: 0000-0002-7724-7445 (2015). Baseline social amotivation predicts 1-year functioning in UHR subjects: A validation and prospective investigation. Eur. Neuropsychopharmacol., 25 (12). S. 2187 - 2197. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1873-7862

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Abstract

Social amotivation and diminished expression have been reported to underlie negative symptomatology in schizophrenia. In the current study we sought to establish and validate these negative symptom domains in a large cohort of schizophrenia subjects (n=887) and individuals who are deemed to be Ultra-High Risk (UHR) for psychosis. Confirmatory factor analysis conducted on PANSS item domains demonstrate that the dual negative symptom domains exist in schizophrenia and UHR subjects. We further sought to examine if these negative symptom domains were associated with functioning in UHR subjects. Linear regression analyses confirmed that social amotivation predicted functioning in UHR subjects prospectively at 1 year follow up. Results suggest that the association between social amotivation and functioning is generalisable beyond schizophrenia populations to those who are at-risk of developing psychosis. Social amotivation may be an important dimensional clinical construct to be studied across a range of psychiatric conditions. (C) 2015 Elsevier B.V. and ECNR All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lam, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Rashid, Nur Amirah Abdul UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Sara-Ann UNSPECIFIED UNSPECIFIED UNSPECIFIED Lim, Jeanette UNSPECIFIED UNSPECIFIED UNSPECIFIED Foussias, George UNSPECIFIED UNSPECIFIED UNSPECIFIED Fervaha, Gagan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrman, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Remington, Gary UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Jimmy UNSPECIFIED orcid.org/0000-0002-7724-7445 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385015
DOI:	10.1016/j.euroneuro.2015.10.007
Journal or Publication Title:	Eur. Neuropsychopharmacol.
Volume:	25
Number:	12
Page Range:	S. 2187 - 2197
Date:	2015
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1873-7862
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEGATIVE-SYNDROME-SCALE; QUALITY-OF-LIFE; FACTORIAL STRUCTURE; 5-FACTOR MODEL; PSYCHOTIC DISORDERS; LONGITUDINAL YOUTH; EPISODE PSYCHOSIS; DEFICIT SYNDROME; FOLLOW-UP; HIGH-RISK Multiple languages Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38501