Universität zu Köln

Schuler-Thurner, B., Bartz-Schmidt, K. -U., Bornfeld, N., Cursiefen, C., Fuisting, B., Grisanti, S., Heindl, L. M., Holbach, L., Keserue, M., Knorr, H., Koch, K., Kruse, F., Meiller, R., Metz, C., Meyer-ter-Vehn, T., Much, M., Reinsberg, M., Schliep, S., Seitz, B., Schuler, G., Suesskind, D., Viestenz, A., Wagenfeld, L. and Zeschnigk, M. (2015). Immunotherapy of uveal melanoma: vaccination against cancer. Multicenter adjuvant phase 3 vaccination study using dendritic cells laden with tumor RNA for large newly diagnosed uveal melanoma. Ophthalmologe, 112 (12). S. 1017 - 1022. NEW YORK: SPRINGER. ISSN 1433-0423

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Abstract

Uveal melanomas are the most common malignant tumors of the eye. With modern molecular biological diagnostic methods, such as chromosome 3 typing and gene expression analysis, these tumors can be categorized into highly aggressive (monosomy 3, class II) and less aggressive forms. This molecular biological stratification is primarily important for determining the risk of these tumors as no therapy is currently available that is able to prevent or delay metastases. A randomized study of patients with a poor prognosis (monosomy 3) is currently being carried out in order to determine whether a cancer vaccine prepared from autologous (patient's own) dendritic cells and uveal melanoma RNA can prevent or delay progression and further metastases of this extremely aggressive form of cancer. Inclusion in the uveal melanoma study, which hopes to provide a potential therapeutic option for patients, is only possible if patients are referred to an institution that is able to manufacture and provide this vaccination before the patient is operated on or treated with radiation. Untreated tumor material is necessary for producing the vaccine on an individualized patient basis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schuler-Thurner, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartz-Schmidt, K. -U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bornfeld, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuisting, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grisanti, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, L. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holbach, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Keserue, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knorr, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kruse, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meiller, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Metz, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer-ter-Vehn, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Much, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinsberg, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schliep, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seitz, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuler, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Suesskind, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Viestenz, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagenfeld, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeschnigk, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385197
DOI:	10.1007/s00347-015-0162-z
Journal or Publication Title:	Ophthalmologe
Volume:	112
Number:	12
Page Range:	S. 1017 - 1022
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0423
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THERAPY Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38519