Universität zu Köln

Koch, Kristina, Koch, Nora, de Silva, Ute Sandaradura, Jung, Norma, zur Wiesch, Julian Schulze, Faetkenheuer, Gerd, Hartmann, Pia, Romerio, Fabio and Lehmann, Clara ORCID: 0000-0002-7042-1578 (2015). Increased Frequency of CD49b/LAG-3(+) Type 1 Regulatory T Cells in HIV-Infected Individuals. Aids Res. Hum. Retrovir., 31 (12). S. 1238 - 1247. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1931-8405

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Abstract

In HIV-1 infection elevated serum levels of interferon- (IFN-) and interleukin-10 (IL-10) are associated with immune hyperactivation and disease progression. Recently, coexpression of CD49b and LAG-3 was shown to identify Type 1 regulatory T (Tr1) cells, which secrete large amounts of the immunosuppressive cytokine IL-10. We analyzed the frequency of CD49b/LAG-3(+) Tr1 cells in the peripheral blood of HIV-infected individuals at different stages of the disease. We found increased levels of CD49b/LAG-3(+) Tr1 cells as well as IL-10 in HIV patients. With disease progression, Tr1 cells negatively correlate with frequency of plasmacytoid dendritic cells (pDCs), the main producers of IFN-. However, elevated IL-10 levels could not be ascribed to the CD49b/LAG-3(+)Tr1 cell population. Moreover, we showed in vitro that IFN- leads to an upregulation of IL-10 as well as CD49b/LAG-3(+) Tr1 cell counts in healthy controls, recapitulating effects observed in vivo during HIV infection. Our results suggest that overexpression of IFN- during HIV infection drives the generation of CD49b/LAG-3(+) Tr1 cells and the immunosuppressive cytokine IL-10. Furthermore, it remains unclear whether elevated IL-10 levels are beneficial or detrimental in regard to disease progression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koch, Kristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED de Silva, Ute Sandaradura UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Norma UNSPECIFIED UNSPECIFIED UNSPECIFIED zur Wiesch, Julian Schulze UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Romerio, Fabio UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Clara UNSPECIFIED orcid.org/0000-0002-7042-1578 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385718
DOI:	10.1089/aid.2014.0356
Journal or Publication Title:	Aids Res. Hum. Retrovir.
Volume:	31
Number:	12
Page Range:	S. 1238 - 1247
Date:	2015
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1931-8405
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN PERIPHERAL-BLOOD; DENDRITIC CELLS; INTERLEUKIN-10 PRODUCTION; ANTIRETROVIRAL THERAPY; LONGITUDINAL ANALYSIS; DISEASE PROGRESSION; IMMUNE ACTIVATION; INTERFERON-GAMMA; RHESUS MACAQUES Multiple languages Immunology; Infectious Diseases; Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38571