Universität zu Köln

Tahmasian, Masoud, Rochhausen, Luisa, Maier, Franziska, Williamson, Kim L., Drzezga, Alexander, Timmermann, Lars, Van Eimeren, Thilo and Eggers, Carsten (2015). Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson's Disease. Front. Behav. Neurosci., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5153

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Abstract

Various neuroimaging studies demonstrated that the fronto-insular network is implicated in impulsive behavior. We compared glucose metabolism (as a proxy measure of neural activity) among 24 patients with Parkinson's disease (PD) who presented with low or high levels of impulsivity based on the Barratt Impulsiveness Scale 11 (BIS) scores. Subjects underwent 18-fluorodeoxyglucose positron emission tomography (FDG-PET) and the voxel-wise group difference of FDG-metabolism was analyzed in Statistical Parametric Mapping (SPM8). Subsequently, we performed a partial correlation analysis between the FDG-metabolism and BIS scores, controlling for covariates (i.e., age, sex, severity of disease and levodopa equivalent daily doses). Voxel-wise group comparison revealed higher FDG-metabolism in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and right insula in patients with higher impulsivity scores. Moreover, there was a positive correlation between the FDG-metabolism and BIS scores. Our findings provide evidence that high impulsivity is associated with increased FDG-metabolism within the fronto-insular network in PD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tahmasian, Masoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Rochhausen, Luisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Williamson, Kim L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386686
DOI:	10.3389/fnbeh.2015.00317
Journal or Publication Title:	Front. Behav. Neurosci.
Volume:	9
Date:	2015
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5153
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BORDERLINE PERSONALITY-DISORDER; ANTERIOR CINGULATE CORTEX; VOXEL-BASED MORPHOMETRY; VON ECONOMO NEURONS; ORBITOFRONTAL CORTEX; PREFRONTAL CORTEX; ALZHEIMER-DISEASE; BIPOLAR DISORDER; RESPONSE-INHIBITION; CORTICAL THICKNESS Multiple languages Behavioral Sciences; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38668