Universität zu Köln

Goede, Valentin and Hallek, Michael (2015). Pharmacotherapeutic Management of Chronic Lymphocytic Leukaemia in Patients with Comorbidities: New Agents, New Hope. Drugs Aging, 32 (11). S. 877 - 887. NORTHCOTE: ADIS INT LTD. ISSN 1179-1969

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Abstract

Chronic lymphocytic leukaemia (CLL) is mostly considered a disease of the elderly. As such, many patients present with comorbidities. Several scores allow for a qualitative and quantitative assessment of comorbidity in patients with CLL. Although our knowledge about the impact of comorbidity on outcomes in patients with CLL is still incomplete, it is becoming increasingly apparent that comorbidities could negatively interfere with CLL treatment. Recently, a number of new agents have been approved for use in patients with previously untreated CLL and comorbidities (i.e. obinutuzumab, ofatumumab), as well as in patients with previously treated or high-risk CLL (i.e. idelalisib, ibrutinib). This review discusses the role of comorbidity in patients with CLL, together with the changing treatment landscape for CLL in this patient population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goede, Valentin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-387784
DOI:	10.1007/s40266-015-0308-3
Journal or Publication Title:	Drugs Aging
Volume:	32
Number:	11
Page Range:	S. 877 - 887
Date:	2015
Publisher:	ADIS INT LTD
Place of Publication:	NORTHCOTE
ISSN:	1179-1969
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTI-CD20 MONOCLONAL-ANTIBODY; ILLNESS RATING-SCALE; RITUXIMAB REGIMEN; INITIAL THERAPY; OPEN-LABEL; 1ST-LINE TREATMENT; PLUS CHLORAMBUCIL; FLUDARABINE; CYCLOPHOSPHAMIDE; OFATUMUMAB Multiple languages Geriatrics & Gerontology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38778