Universität zu Köln

Jakobshagen, Kristin, Ward, Beate, Baschuk, Nikola, Huss, Sebastian, Brunn, Anna, Malecki, Monika, Fiolka, Michael, Rappl, Gunther, Corogeanu, Diana, Karow, Ulrike, Schiller, Petra, Abken, Hinrich, Heukamp, Lukas C., Deckert, Martina, Kroenke, Martin and Utermoehlen, Olaf (2015). Endogenous Il10 Alleviates the Systemic Antiviral Cellular Immune Response and T Cell-Mediated Immunopathology in Select Organs of Acutely LCMV-Infected Mice. Am. J. Pathol., 185 (11). S. 3025 - 3039. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1525-2191

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Abstract

The immunoregulatory cytokine IL-10 suppresses T-cell immunity. The complementary question, whether IL-10 is also involved in Limiting the collateral damage of vigorous T cell responses, has not been addressed in detail. Here, we report that the particularly strong virus-specific immune response during acute primary infection with the Lymphocytic choriomeningitis virus (LCMV) in mice is significantly further increased in Il10 deficient mice, particularly regarding frequencies and cytotoxic activity of CD8(+) T cells. This increase results in exacerbating immunopathology in select organs, ranging from transient local swelling to an increased risk for mortality. Remarkably, LCMV-induced, T cell mediated hepatitis is not affected by endogenous Il10. The alleviating effect of Il10 on LCMV-induced immunopathology was found to be operative in delayed-type hypersensitivity footpad-swelling reaction and in debilitating meningitis in mice of both the C57BL/6 and BALB/c strains. These strains are prototypic counterpoles for genetically imprinted type 1-biased versus type 2-biased T cell mediated immune responses against various infectious pathogens. However, during acute LCMV infection, neither systemic cytokine patterns nor the impact of Il10 on LCMV-induced immunopathology differed conspicuously between these two strains of mice. This study documents a physiological role of Il10 in the regulation of a balanced T-cell response limiting immunopathological damage.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jakobshagen, Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ward, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Baschuk, Nikola UNSPECIFIED UNSPECIFIED UNSPECIFIED Huss, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Brunn, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Malecki, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiolka, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Rappl, Gunther UNSPECIFIED UNSPECIFIED UNSPECIFIED Corogeanu, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Karow, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiller, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Abken, Hinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Heukamp, Lukas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroenke, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Utermoehlen, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-388090
DOI:	10.1016/j.ajpath.2015.07.019
Journal or Publication Title:	Am. J. Pathol.
Volume:	185
Number:	11
Page Range:	S. 3025 - 3039
Date:	2015
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1525-2191
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPHOCYTIC CHORIOMENINGITIS VIRUS; PERSISTENT VIRAL-INFECTION; DENDRITIC CELLS; IL-10; INTERLEUKIN-10; CYTOMEGALOVIRUS; CLEARANCE; HEPATITIS; SUSCEPTIBILITY; PATHOGENESIS Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38809