Kisaka, Tomohiko, Cox, Timothy A., Dumitrescu, Daniel and Wasserman, Karlman (2015). CO2 pulse and acid-base status during increasing work rate exercise in health and disease. Respir. Physiol. Neuro., 218. S. 46 - 57. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1878-1519

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Abstract

The CO2 pulse ((V) over dotCO(2)/heart rate), analogous to the O-2 pulse ((V) over dotO(2)/heart rate), was calculated during cardiopulmonary exercise testing and evaluated in normal and diseased states. Our aim was to define its application in its release in excess of that from (V) over dontCO(2)/heart rate in the presence of impaired cardiovascular and lung function. In the current study, forty-five patients were divided into six physiological states: normal, exercise-induced myocardial ischemia, chronic heart failure, pulmonary vasculopathy, chronic obstructive pulmonary disease, and interstitial lung disease. We subtracted the O-2 pulse from the CO2 pulse to determine the exhaled CO2 that could be attributed to CO2 pulse of buffering of lactic acid. The difference between the CO2 pulse and O-2 pulse ((V) over dotCO(2)/heart rate-(V) over dotO(2)/heart rate) includes CO2 generated from HCO3- buffering of lactic acid. The accumulated CO2 per body mass was found to be significantly correlated with the corresponding [HCO3-] decrease (R-2 = 0.72; P<0.0001). In summary, the increase in CO2 pulse over the O-2 pulse accounted for the anaerobically-generated excess-CO2 in each of the physiological states and correlated with the decreases in the arterial Bicarbonate concentration. (C) 2015 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kisaka, TomohikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, Timothy A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumitrescu, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wasserman, KarlmanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-388358
DOI: 10.1016/j.resp.2015.07.005
Journal or Publication Title: Respir. Physiol. Neuro.
Volume: 218
Page Range: S. 46 - 57
Date: 2015
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1878-1519
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GAS-EXCHANGE; ANAEROBIC THRESHOLD; RISKMultiple languages
Physiology; Respiratory SystemMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38835

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