Szczepanowska, Karolina ORCID: 0000-0003-4689-2350 and Trifunovic, Aleksandra (2015). Different faces of mitochondrial DNA mutators. Biochim. Biophys. Acta-Bioenerg., 1847 (11). S. 1362 - 1373. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1879-2650
Full text not available from this repository.Abstract
A number of studies have shown that ageing is associated with increased amounts of mtDNA deletions and/or point mutations in a variety of species as diverse as Caenorhabditis elegans, Drosophila melanogaster, mice, rats, dogs, primates and humans. This detected vulnerability of mtDNA has led to the suggestion that the accumulation of somatic mtDNA mutations might arise from increased oxidative damage and could play an important role in the ageing process by producing cells with a decreased oxidative capacity. However, the vast majority of DNA polymorphisms and disease-causing base-substitution mutations and age-associated mutations that have been detected in human mtDNA are transition mutations. They are likely arising from the slight infidelity of the mitochondrial DNA polymerase. Indeed, transition mutations are also the predominant type of mutation found in mtDNA mutator mice, a model for premature ageing caused by increased mutation load due to the error prone mitochondrial DNA synthesis. These particular misincorporation events could also be exacerbated by dNTP pool imbalances. The role of different repair, replication and maintenance mechanisms that contribute to mtDNA integrity and mutagenesis will be discussed in details in this article. This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging. (c) 2015 Elsevier B.V. All rights reserved.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-388580 | ||||||||||||
DOI: | 10.1016/j.bbabio.2015.05.016 | ||||||||||||
Journal or Publication Title: | Biochim. Biophys. Acta-Bioenerg. | ||||||||||||
Volume: | 1847 | ||||||||||||
Number: | 11 | ||||||||||||
Page Range: | S. 1362 - 1373 | ||||||||||||
Date: | 2015 | ||||||||||||
Publisher: | ELSEVIER SCIENCE BV | ||||||||||||
Place of Publication: | AMSTERDAM | ||||||||||||
ISSN: | 1879-2650 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/38858 |
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