Universität zu Köln

Szczepanowska, Karolina ORCID: 0000-0003-4689-2350 and Trifunovic, Aleksandra (2015). Different faces of mitochondrial DNA mutators. Biochim. Biophys. Acta-Bioenerg., 1847 (11). S. 1362 - 1373. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1879-2650

Full text not available from this repository.

Abstract

A number of studies have shown that ageing is associated with increased amounts of mtDNA deletions and/or point mutations in a variety of species as diverse as Caenorhabditis elegans, Drosophila melanogaster, mice, rats, dogs, primates and humans. This detected vulnerability of mtDNA has led to the suggestion that the accumulation of somatic mtDNA mutations might arise from increased oxidative damage and could play an important role in the ageing process by producing cells with a decreased oxidative capacity. However, the vast majority of DNA polymorphisms and disease-causing base-substitution mutations and age-associated mutations that have been detected in human mtDNA are transition mutations. They are likely arising from the slight infidelity of the mitochondrial DNA polymerase. Indeed, transition mutations are also the predominant type of mutation found in mtDNA mutator mice, a model for premature ageing caused by increased mutation load due to the error prone mitochondrial DNA synthesis. These particular misincorporation events could also be exacerbated by dNTP pool imbalances. The role of different repair, replication and maintenance mechanisms that contribute to mtDNA integrity and mutagenesis will be discussed in details in this article. This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging. (c) 2015 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Szczepanowska, Karolina UNSPECIFIED orcid.org/0000-0003-4689-2350 UNSPECIFIED Trifunovic, Aleksandra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-388580
DOI:	10.1016/j.bbabio.2015.05.016
Journal or Publication Title:	Biochim. Biophys. Acta-Bioenerg.
Volume:	1847
Number:	11
Page Range:	S. 1362 - 1373
Date:	2015
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1879-2650
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRIPTION FACTOR-A; POLYMERASE-GAMMA; POINT MUTATIONS; LIGASE-III; OXIDATIVE STRESS; REPAIR ENZYME; DAMAGE REPAIR; INTRACELLULAR-LOCALIZATION; DROSOPHILA-MELANOGASTER; PURIFYING SELECTION Multiple languages Biochemistry & Molecular Biology; Biophysics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38858