Day, Felix R., Ruth, Katherine S., Thompson, Deborah J., Lunetta, Kathryn L., Pervjakova, Natalia, Chasman, Daniel I., Stolk, Lisette, Finucane, Hilary K., Sulem, Patrick, Bulik-Sullivan, Brendan, Esko, Tonu, Johnson, Andrew D., Elks, Cathy E., Franceschini, Nora, He, Chunyan, Altmaier, Elisabeth, Brody, Jennifer A., Franke, Lude L., Huffman, Jennifer E., Keller, Margaux F., McArdle, Patrick F., Nutile, Teresa, Porcu, Eleonora, Robino, Antonietta ORCID: 0000-0003-2152-2353, Rose, Lynda M., Schick, Ursula M., Smith, Jennifer A., Teumer, Alexander ORCID: 0000-0002-8309-094X, Traglia, Michela, Vuckovic, Dragana ORCID: 0000-0001-9343-6142, Yao, Jie, Zhao, Wei, Albrecht, Eva, Amin, Najaf ORCID: 0000-0002-8944-1771, Corre, Tanguy, Hottenga, Jouke-Jan, Mangino, Massimo, Smith, Albert V., Tanaka, Toshiko, Abecasis, Goncalo R., Andrulis, Irene L., Anton-Culver, Hoda, Antoniou, Antonis C., Arndt, Volker ORCID: 0000-0001-9320-8684, Arnold, Alice M., Barbieri, Caterina, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bernstein, Leslie, Bielinski, Suzette J., Blomqvist, Carl ORCID: 0000-0003-3041-1938, Boerwinkle, Eric, Bogdanova, Natalia V., Bojesen, Stig E., Bolla, Manjeet K., Borresen-Dale, Anne-Lise, Boutin, Thibaud S., Brauch, Hiltrud ORCID: 0000-0001-7531-2736, Brenner, Hermann ORCID: 0000-0002-6129-1572, Bruening, Thomas, Burwinkel, Barbara, Campbell, Archie ORCID: 0000-0003-0198-5078, Campbell, Harry ORCID: 0000-0002-6169-6262, Chanock, Stephen J., Chapman, J. Ross, Chen, Yii-Der Ida, Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Couch, Fergus J., Coviello, Andrea D., Cox, Angela ORCID: 0000-0002-5138-1099, Czene, Kamila, Darabi, Hatef, De Vivo, Immaculata, Demerath, Ellen W., Dennis, Joe, Devilee, Peter ORCID: 0000-0002-8023-2009, Doerk, Thilo, dos-Santos-Silva, Isabel, Dunning, Alison M., Eicher, John D., Fasching, Peter A., Faul, Jessica D., Figueroa, Jonine, Flesch-Janys, Dieter, Gandin, Ilaria, Garcia, Melissa E., Garcia-Closas, Montserrat, Giles, Graham G., Girotto, Giorgia G., Goldberg, Mark S., Gonzalez-Neira, Anna, Goodarzi, Mark O., Grove, Megan L., Gudbjartsson, Daniel F., Guenel, Pascal ORCID: 0000-0002-8359-518X, Guo, Xiuqing, Haiman, Christopher A., Hall, Per, Hamann, Ute, Henderson, Brian E., Hocking, Lynne J., Hofman, Albert, Homuth, Georg, Hooning, Maartje J., Hopper, John L., Hu, Frank B., Huang, Jinyan, Humphreys, Keith, Hunter, David J., Jakubowska, Anna ORCID: 0000-0002-5650-0501, Jones, Samuel E., Kabisch, Maria, Karasik, David ORCID: 0000-0002-8826-0530, Knight, Julia A., Kolcic, Ivana ORCID: 0000-0001-7918-6052, Kooperberg, Charles, Kosma, Veli-Matti, Kriebel, Jennifer ORCID: 0000-0003-4270-018X, Kristensen, Vessela, Lambrechts, Diether ORCID: 0000-0002-3429-302X, Langenberg, Claudia ORCID: 0000-0002-5017-7344, Li, Jingmei ORCID: 0000-0001-8587-7511, Li, Xin, Lindstroem, Sara, Liu, Yongmei, Luan, Jian'an, Lubinski, Jan ORCID: 0000-0003-2931-3003, Maegi, Reedik, Mannermaa, Arto, Manz, Judith, Margolin, Sara, Marten, Jonathan ORCID: 0000-0001-6916-2014, Martin, Nicholas G., Masciullo, Corrado, Meindl, Alfons, Michailidou, Kyriaki ORCID: 0000-0001-7065-1237, Mihailov, Evelin, Milani, Lili ORCID: 0000-0002-5323-3102, Milne, Roger L., Mueller-Nurasyid, Martina, Nalls, Michael, Neale, Benjamin M., Nevanlinna, Heli, Neven, Patrick, Newman, Anne B. ORCID: 0000-0002-0106-1150, Nordestgaard, Borge G., Olson, Janet E., Padmanabhan, Sandosh ORCID: 0000-0003-3869-5808, Peterlongo, Paolo ORCID: 0000-0001-6951-6855, Peters, Ulrike, Petersmann, Astrid, Peto, Julian, Pharoah, Paul D. P., Pirastu, Nicola N., Pirie, Ailith, Pistis, Giorgio, Polasek, Ozren ORCID: 0000-0002-5765-1862, Porteous, David, Psaty, Bruce M., Pylkas, Katri ORCID: 0000-0002-2449-0521, Radice, Paolo ORCID: 0000-0001-6298-4111, Raffel, Leslie J., Rivadeneira, Fernando ORCID: 0000-0001-9435-9441, Rudan, Igor ORCID: 0000-0001-6993-6884, Rudolph, Anja, Ruggiero, Daniela, Sala, Cinzia F., Sanna, Serena, Sawyer, Elinor J., Schlessinger, David, Schmidt, Marjanka K., Schmidt, Frank ORCID: 0000-0001-5406-3988, Schmutzler, Rita K., Schoemaker, Minouk J., Scott, Robert A., Seynaeve, Caroline M., Simard, Jacques, Sorice, Rossella, Southey, Melissa C., Stoeckl, Doris, Strauch, Konstantin, Swerdlow, Anthony ORCID: 0000-0001-5550-4159, Taylor, Kent D., Thorsteinsdottir, Unnur, Toland, Amanda E., Tomlinson, Ian, Truong, Therese ORCID: 0000-0002-2943-6786, Tryggvadottir, Laufey ORCID: 0000-0001-8067-9030, Turner, Stephen T., Vozzi, Diego, Wang, Qin, Wellons, Melissa, Willemsen, Gonneke ORCID: 0000-0003-3755-0236, Wilson, James F., Winqvist, Robert, Wolffenbuttel, Bruce B. H. R., Wright, Alan F., Yannoukakos, Drakoulis ORCID: 0000-0001-7509-3510, Zemunik, Tatijana, Zheng, Wei ORCID: 0000-0003-1226-070X, Zygmunt, Marek, Bergmann, Sven ORCID: 0000-0002-6785-9034, Boomsma, Dorret I., Buring, Julie E., Ferrucci, Luigi, Montgomery, Grant W., Gudnason, Vilmundur ORCID: 0000-0001-5696-0084, Spector, Tim D., van Duijn, Cornelia M., Alizadeh, Behrooz Z., Ciullo, Marina ORCID: 0000-0002-9621-9984, Crisponi, Laura ORCID: 0000-0001-9128-8537, Easton, Douglas F., Gasparini, Paolo P., Gieger, Christian, Harris, Tamara B., Hayward, Caroline, Kardia, Sharon L. R., Kraft, Peter ORCID: 0000-0002-4472-8103, McKnight, Barbara, Metspalu, Andres, Morrison, Alanna C., Reiner, Alex P., Ridker, Paul M., Rotter, Jerome I., Toniolo, Daniela ORCID: 0000-0001-9545-6032, Uitterlinden, Andre G., Ulivi, Sheila, Voelzke, Henry, Wareham, Nicholas J., Weir, David R., Yerges-Armstrong, Laura M., Price, Alkes L., Stefansson, Kari, Visser, Jenny A., Ong, Ken K., Chang-Claude, Jenny, Murabito, Joanne M., Perry, John R. B. and Murray, Anna ORCID: 0000-0002-2351-2522 (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genet., 47 (11). S. 1294 - 1306. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1718

Full text not available from this repository.

Abstract

Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in similar to 70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (similar to 6% increase in risk per year; P = 3 x 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Day, Felix R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruth, Katherine S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thompson, Deborah J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lunetta, Kathryn L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pervjakova, NataliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chasman, Daniel I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stolk, LisetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finucane, Hilary K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sulem, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bulik-Sullivan, BrendanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esko, TonuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, Andrew D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elks, Cathy E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franceschini, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
He, ChunyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altmaier, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brody, Jennifer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, Lude L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huffman, Jennifer E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keller, Margaux F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McArdle, Patrick F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nutile, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porcu, EleonoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robino, AntoniettaUNSPECIFIEDorcid.org/0000-0003-2152-2353UNSPECIFIED
Rose, Lynda M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schick, Ursula M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Jennifer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teumer, AlexanderUNSPECIFIEDorcid.org/0000-0002-8309-094XUNSPECIFIED
Traglia, MichelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vuckovic, DraganaUNSPECIFIEDorcid.org/0000-0001-9343-6142UNSPECIFIED
Yao, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, WeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albrecht, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amin, NajafUNSPECIFIEDorcid.org/0000-0002-8944-1771UNSPECIFIED
Corre, TanguyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hottenga, Jouke-JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mangino, MassimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Albert V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tanaka, ToshikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abecasis, Goncalo R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anton-Culver, HodaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arndt, VolkerUNSPECIFIEDorcid.org/0000-0001-9320-8684UNSPECIFIED
Arnold, Alice M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbieri, CaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckmann, Matthias W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beeghly-Fadiel, AliciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernstein, LeslieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bielinski, Suzette J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blomqvist, CarlUNSPECIFIEDorcid.org/0000-0003-3041-1938UNSPECIFIED
Boerwinkle, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bogdanova, Natalia V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bojesen, Stig E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bolla, Manjeet K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borresen-Dale, Anne-LiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boutin, Thibaud S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brauch, HiltrudUNSPECIFIEDorcid.org/0000-0001-7531-2736UNSPECIFIED
Brenner, HermannUNSPECIFIEDorcid.org/0000-0002-6129-1572UNSPECIFIED
Bruening, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burwinkel, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campbell, ArchieUNSPECIFIEDorcid.org/0000-0003-0198-5078UNSPECIFIED
Campbell, HarryUNSPECIFIEDorcid.org/0000-0002-6169-6262UNSPECIFIED
Chanock, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chapman, J. RossUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, Yii-Der IdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chenevix-Trench, GeorgiaUNSPECIFIEDorcid.org/0000-0002-1878-2587UNSPECIFIED
Couch, Fergus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coviello, Andrea D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, AngelaUNSPECIFIEDorcid.org/0000-0002-5138-1099UNSPECIFIED
Czene, KamilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Darabi, HatefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Vivo, ImmaculataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demerath, Ellen W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dennis, JoeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devilee, PeterUNSPECIFIEDorcid.org/0000-0002-8023-2009UNSPECIFIED
Doerk, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
dos-Santos-Silva, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunning, Alison M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eicher, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fasching, Peter A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faul, Jessica D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Figueroa, JonineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flesch-Janys, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gandin, IlariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia, Melissa E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Closas, MontserratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giles, Graham G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Girotto, Giorgia G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldberg, Mark S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez-Neira, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goodarzi, Mark O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grove, Megan L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gudbjartsson, Daniel F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guenel, PascalUNSPECIFIEDorcid.org/0000-0002-8359-518XUNSPECIFIED
Guo, XiuqingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haiman, Christopher A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hall, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamann, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henderson, Brian E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hocking, Lynne J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofman, AlbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Homuth, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooning, Maartje J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hu, Frank B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, JinyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Humphreys, KeithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunter, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakubowska, AnnaUNSPECIFIEDorcid.org/0000-0002-5650-0501UNSPECIFIED
Jones, Samuel E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kabisch, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karasik, DavidUNSPECIFIEDorcid.org/0000-0002-8826-0530UNSPECIFIED
Knight, Julia A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolcic, IvanaUNSPECIFIEDorcid.org/0000-0001-7918-6052UNSPECIFIED
Kooperberg, CharlesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kosma, Veli-MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kriebel, JenniferUNSPECIFIEDorcid.org/0000-0003-4270-018XUNSPECIFIED
Kristensen, VesselaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lambrechts, DietherUNSPECIFIEDorcid.org/0000-0002-3429-302XUNSPECIFIED
Langenberg, ClaudiaUNSPECIFIEDorcid.org/0000-0002-5017-7344UNSPECIFIED
Li, JingmeiUNSPECIFIEDorcid.org/0000-0001-8587-7511UNSPECIFIED
Li, XinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindstroem, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, YongmeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luan, Jian'anUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lubinski, JanUNSPECIFIEDorcid.org/0000-0003-2931-3003UNSPECIFIED
Maegi, ReedikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mannermaa, ArtoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manz, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Margolin, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marten, JonathanUNSPECIFIEDorcid.org/0000-0001-6916-2014UNSPECIFIED
Martin, Nicholas G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Masciullo, CorradoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meindl, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michailidou, KyriakiUNSPECIFIEDorcid.org/0000-0001-7065-1237UNSPECIFIED
Mihailov, EvelinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milani, LiliUNSPECIFIEDorcid.org/0000-0002-5323-3102UNSPECIFIED
Milne, Roger L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Nurasyid, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nalls, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neale, Benjamin M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nevanlinna, HeliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neven, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Newman, Anne B.UNSPECIFIEDorcid.org/0000-0002-0106-1150UNSPECIFIED
Nordestgaard, Borge G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olson, Janet E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Padmanabhan, SandoshUNSPECIFIEDorcid.org/0000-0003-3869-5808UNSPECIFIED
Peterlongo, PaoloUNSPECIFIEDorcid.org/0000-0001-6951-6855UNSPECIFIED
Peters, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petersmann, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peto, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pharoah, Paul D. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pirastu, Nicola N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pirie, AilithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pistis, GiorgioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polasek, OzrenUNSPECIFIEDorcid.org/0000-0002-5765-1862UNSPECIFIED
Porteous, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Psaty, Bruce M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pylkas, KatriUNSPECIFIEDorcid.org/0000-0002-2449-0521UNSPECIFIED
Radice, PaoloUNSPECIFIEDorcid.org/0000-0001-6298-4111UNSPECIFIED
Raffel, Leslie J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rivadeneira, FernandoUNSPECIFIEDorcid.org/0000-0001-9435-9441UNSPECIFIED
Rudan, IgorUNSPECIFIEDorcid.org/0000-0001-6993-6884UNSPECIFIED
Rudolph, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruggiero, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sala, Cinzia F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanna, SerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sawyer, Elinor J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlessinger, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Marjanka K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, FrankUNSPECIFIEDorcid.org/0000-0001-5406-3988UNSPECIFIED
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Scott, Robert A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seynaeve, Caroline M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simard, JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sorice, RossellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, Melissa C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoeckl, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strauch, KonstantinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Swerdlow, AnthonyUNSPECIFIEDorcid.org/0000-0001-5550-4159UNSPECIFIED
Taylor, Kent D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thorsteinsdottir, UnnurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toland, Amanda E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Wright, Alan F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yannoukakos, DrakoulisUNSPECIFIEDorcid.org/0000-0001-7509-3510UNSPECIFIED
Zemunik, TatijanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zheng, WeiUNSPECIFIEDorcid.org/0000-0003-1226-070XUNSPECIFIED
Zygmunt, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergmann, SvenUNSPECIFIEDorcid.org/0000-0002-6785-9034UNSPECIFIED
Boomsma, Dorret I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buring, Julie E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrucci, LuigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, Grant W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gudnason, VilmundurUNSPECIFIEDorcid.org/0000-0001-5696-0084UNSPECIFIED
Spector, Tim D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Duijn, Cornelia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alizadeh, Behrooz Z.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ciullo, MarinaUNSPECIFIEDorcid.org/0000-0002-9621-9984UNSPECIFIED
Crisponi, LauraUNSPECIFIEDorcid.org/0000-0001-9128-8537UNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gasparini, Paolo P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gieger, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harris, Tamara B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayward, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kardia, Sharon L. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraft, PeterUNSPECIFIEDorcid.org/0000-0002-4472-8103UNSPECIFIED
McKnight, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metspalu, AndresUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morrison, Alanna C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiner, Alex P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ridker, Paul M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rotter, Jerome I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toniolo, DanielaUNSPECIFIEDorcid.org/0000-0001-9545-6032UNSPECIFIED
Uitterlinden, Andre G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ulivi, SheilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voelzke, HenryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wareham, Nicholas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weir, David R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yerges-Armstrong, Laura M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Price, Alkes L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stefansson, KariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser, Jenny A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ong, Ken K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang-Claude, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murabito, Joanne M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perry, John R. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murray, AnnaUNSPECIFIEDorcid.org/0000-0002-2351-2522UNSPECIFIED
URN: urn:nbn:de:hbz:38-388922
DOI: 10.1038/ng.3412
Journal or Publication Title: Nature Genet.
Volume: 47
Number: 11
Page Range: S. 1294 - 1306
Date: 2015
Publisher: NATURE PUBLISHING GROUP
Place of Publication: NEW YORK
ISSN: 1546-1718
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OVARIAN FAILURE; HOMOLOGOUS RECOMBINATION; NATURAL MENOPAUSE; WIDE ASSOCIATION; CELL-TYPES; BRCA1; LOCI; AGE; RECEPTOR; INSUFFICIENCYMultiple languages
Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38892

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