Universität zu Köln

Troilo, Helen ORCID: 0000-0003-0537-1786, Barrett, Anne L., Wohl, Alexander P., Jowitt, Thomas A., Collins, Richard F., Bayley, Christopher P., Zuk, Alexandra V., Sengle, Gerhard and Baldock, Clair ORCID: 0000-0003-3497-1959 (2015). The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity. Biochem. Soc. Trans., 43. S. 795 - 801. LONDON: PORTLAND PRESS LTD. ISSN 1470-8752

Full text not available from this repository.

Abstract

Chordin-mediated regulation of bone morphogenetic protein (BMP) family growth factors is essential in early embryogenesis and adult homoeostasis. Chordin binds to BMPs through cysteine-rich von Willebrand factor type C (vWC) homology domains and blocks them from interacting with their cell surface receptors. These domains also self-associate and enable chordin to target related proteins to fine-tune BMP regulation. The chordin-BMP inhibitory complex is strengthened by the secreted glycoprotein twisted gastrulation (Tsg); however, inhibition is relieved by cleavage of chordin at two specific sites by tolloid family metalloproteases. As Tsg enhances this cleavage process, it serves a dual role as both promoter and inhibitor of BMP signalling. Recent developments in chordin research suggest that rather than simply being by-products, the cleavage fragments of chordin continue to play a role in BMP regulation. In particular, chordin cleavage at the C-terminus potentiates its anti-BMP activity in a type-specific manner.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Troilo, Helen UNSPECIFIED orcid.org/0000-0003-0537-1786 UNSPECIFIED Barrett, Anne L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohl, Alexander P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jowitt, Thomas A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Collins, Richard F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bayley, Christopher P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zuk, Alexandra V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sengle, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldock, Clair UNSPECIFIED orcid.org/0000-0003-3497-1959 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-391861
DOI:	10.1042/BST20150071
Journal or Publication Title:	Biochem. Soc. Trans.
Volume:	43
Page Range:	S. 795 - 801
Date:	2015
Publisher:	PORTLAND PRESS LTD
Place of Publication:	LONDON
ISSN:	1470-8752
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE MORPHOGENETIC PROTEIN; TWISTED GASTRULATION; INHIBITOR; PROMOTES; BINDING; DOMAIN Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39186