Universität zu Köln

Horn, Thorsten, Hilbrant, Maarten and Panfilio, Kristen A. (2015). Evolution of epithelial morphogenesis: phenotypic integration across multiple levels of biological organization. Front. Genet., 6. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-8021

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Abstract

Morphogenesis involves the dynamic reorganization of cell and tissue shapes to create the three-dimensional body. Intriguingly, different species have evolved different morphogenetic processes to achieve the same general outcomes during embryonic development. How are meaningful comparisons between species made, and where do the differences lie? In this Perspective, we argue that examining the evolution of embryonic morphogenesis requires the simultaneous consideration of different levels of biological organization: (1) genes, (2) cells, (3) tissues, and (4) the entire egg, or other gestational context. To illustrate the importance of integrating these levels, we use the extraembryonic epithelia of insects a lineage-specific innovation and evolutionary hotspot as an exemplary case study. We discuss how recent functional data, primarily from RNAi experiments targeting the Hox3/Zen and U-shaped group transcription factors, provide insights into developmental processes at all four levels. Comparisons of these data from several species both challenge and inform our understanding of homology, in assessing how the process of epithelial morphogenesis has itself evolved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Horn, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilbrant, Maarten UNSPECIFIED UNSPECIFIED UNSPECIFIED Panfilio, Kristen A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-392639
DOI:	10.3389/fgene.2015.00303
Journal or Publication Title:	Front. Genet.
Volume:	6
Date:	2015
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-8021
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DORSAL CLOSURE; DROSOPHILA-MELANOGASTER; ANTENNAPEDIA COMPLEX; ONCOPELTUS-FASCIATUS; TRIBOLIUM-CASTANEUM; HOMEOBOX GENES; HOX GENES; AMNIOSEROSA; TISSUE; CELL Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39263