Universität zu Köln

Syed, Adnan S., Sansone, Alfredo ORCID: 0000-0002-1197-7322, Roener, Sebastian, Nia, Shahrzad Bozorg, Manzini, Ivan ORCID: 0000-0002-3575-9637 and Korsching, Sigrun I. ORCID: 0000-0002-5450-172X (2015). Different expression domains for two closely related amphibian TAARs generate a bimodal distribution similar to neuronal responses to amine odors. Sci Rep, 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Olfactory perception is mediated by a multitude of olfactory receptors, whose expression in the sensory surface, the olfactory epithelium, is spatially regulated. A common theme is the segregation of different olfactory receptors in different expression domains, which in turn leads to corresponding segregation in the neuronal responses to different odor groups. The amphibian olfactory receptor gene family of trace amine associated receptors, in short TAARs, is exceedingly small and allows a comprehensive analysis of spatial expression patterns, as well as a comparison with neuronal responses to the expected ligands for this receptor family, amines. Here we report that TAAR4b exhibits a spatial expression pattern characteristically different in two dimensions from that of TAAR4a, its close homolog. Together, these two genes result in a bimodal distribution resembling that of amine responses as visualized by calcium imaging. A stringent quantitative analysis suggests the involvement of additional olfactory receptors in amphibian responses to amine odors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Syed, Adnan S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sansone, Alfredo UNSPECIFIED orcid.org/0000-0002-1197-7322 UNSPECIFIED Roener, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Nia, Shahrzad Bozorg UNSPECIFIED UNSPECIFIED UNSPECIFIED Manzini, Ivan UNSPECIFIED orcid.org/0000-0002-3575-9637 UNSPECIFIED Korsching, Sigrun I. UNSPECIFIED orcid.org/0000-0002-5450-172X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-393023
DOI:	10.1038/srep13935
Journal or Publication Title:	Sci Rep
Volume:	5
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OLFACTORY RECEPTOR NEURONS; XENOPUS-LAEVIS; EPITHELIUM; MAIN; BULB Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/39302