Universität zu Köln

Morgner, Jessica, Ghatak, Sushmita, Jakobi, Tobias ORCID: 0000-0002-3906-0401, Dieterich, Christoph, Aumailley, Monique and Wickstroem, Sara A. (2015). Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat. Commun., 6. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Stem cells reside in specialized niches that are critical for their function. Quiescent hair follicle stem cells (HFSCs) are confined within the bulge niche, but how the molecular composition of the niche regulates stem cell behaviour is poorly understood. Here we show that integrin-linked kinase (ILK) is a key regulator of the bulge extracellular matrix microenvironment, thereby governing the activation and maintenance of HFSCs. ILK mediates deposition of inverse laminin (LN)-332 and LN-511 gradients within the basement membrane (BM) wrapping the hair follicles. The precise BM composition tunes activities of Wnt and transforming growth factor-b pathways and subsequently regulates HFSC activation. Notably, reconstituting an optimal LN microenvironment restores the altered signalling in ILK-deficient cells. Aberrant stem cell activation in ILK-deficient epidermis leads to increased replicative stress, predisposing the tissue to carcinogenesis. Overall, our findings uncover a critical role for the BM niche in regulating stem cell activation and thereby skin homeostasis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Morgner, Jessica UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghatak, Sushmita UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobi, Tobias UNSPECIFIED orcid.org/0000-0002-3906-0401 UNSPECIFIED Dieterich, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Aumailley, Monique UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickstroem, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-393784
DOI:	10.1038/ncomms9198
Journal or Publication Title:	Nat. Commun.
Volume:	6
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HAIR FOLLICLE MORPHOGENESIS; EXTRACELLULAR-MATRIX; ADHESION; PROLIFERATION; EXPRESSION; LAMININ-511; ACTIVATION; GENERATION; MIGRATION; DYNAMICS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39378