Universität zu Köln

Tischner, Christin and Wenz, Tina (2015). Keep the fire burning: Current avenues in the quest of treating mitochondrial disorders. Mitochondrion, 24. S. 32 - 50. OXFORD: ELSEVIER SCI LTD. ISSN 1872-8278

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Abstract

Mitochondrial diseases are very heterogeneous in their genetic cause and clinical manifestation. During the last few decades progress has been made in the diagnosis of mitochondrial diseases, but an established therapy is so far lacking. Several experimental strategies targeting different points of intervention are currently being assessed world-wide. Numerous mouse models of OXPHOS disorders have become available enabling further optimization and validation of therapeutic strategies and paving the way for future clinical trials. In this review, we provide an update on current developments towards treatment as well as the potential and status of transition into therapeutic use. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tischner, Christin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenz, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-394279
DOI:	10.1016/j.mito.2015.06.002
Journal or Publication Title:	Mitochondrion
Volume:	24
Page Range:	S. 32 - 50
Date:	2015
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1872-8278
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-PENETRATING PEPTIDES; HEREDITARY OPTIC NEUROPATHY; ACTIVATED PROTEIN-KINASE; OPTIMIZED ALLOTOPIC EXPRESSION; NADH-UBIQUINONE OXIDOREDUCTASE; SEQUENCE-SPECIFIC MODIFICATION; CONGENITAL LACTIC-ACIDOSIS; PLACEBO-CONTROLLED TRIAL; LARGE-SCALE DELETIONS; COMPLEX-I DEFICIENCY Multiple languages Cell Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39427