Zinzani, P. L., Sasse, S., Radford, J., Shonukan, O. and Bonthapally, V. (2015). Experience of brentuximab vedotin in relapsed/refractory Hodgkin lymphoma and relapsed/refractory systemic anaplastic large-cell lymphoma in the Named Patient Program: Review of the literature. Crit. Rev. Oncol./Hematol., 95 (3). S. 359 - 370. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-0461
Full text not available from this repository.Abstract
Brentuximab vedotin was made available via a Named Patient Program (NPP) to non-US/Canadian patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) or systemic anaplastic large-cell lymphoma (sALCL) until approval in their respective countries. We re-evaluated the efficacy and safety NPP data in a pooled analysis. Through a systematic literature review, 21 NPP publications were identified describing 14 cohorts (N=245). Among patients with a specified diagnosis, 207 had HL, 28 had ALCL, and one had CD30+ T-cell lymphoma (not specified). In cohorts reporting response, overall response and complete remission rates were 67% and 26%, respectively, in R/R HL, and 75% and 74%, respectively, in R/R ALCL. Incidences of grade 3/4 neurologic and hematologic toxicities were 6% and 12%, respectively; 5% of patients discontinued because of toxicity. In real-world practice, response rates and tolerability to brentximab vedotin are similar to those reported in the two pivotal phase 2 trials in these settings. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Item Type: | Journal Article | ||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-395317 | ||||||||||||||||||||||||
DOI: | 10.1016/j.critrevonc.2015.03.011 | ||||||||||||||||||||||||
Journal or Publication Title: | Crit. Rev. Oncol./Hematol. | ||||||||||||||||||||||||
Volume: | 95 | ||||||||||||||||||||||||
Number: | 3 | ||||||||||||||||||||||||
Page Range: | S. 359 - 370 | ||||||||||||||||||||||||
Date: | 2015 | ||||||||||||||||||||||||
Publisher: | ELSEVIER SCIENCE INC | ||||||||||||||||||||||||
Place of Publication: | NEW YORK | ||||||||||||||||||||||||
ISSN: | 1879-0461 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/39531 |
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