Universität zu Köln

Sengle, Gerhard and Sakai, Lynn V. (2015). The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation? Matrix Biol., 47. S. 3 - 13. AMSTERDAM: ELSEVIER. ISSN 1569-1802

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Abstract

The fibrillins, large extracellular matrix molecules, are polymerized to form microfibrils. The fibrillin microfibril scaffold is populated by microfibril-associated proteins and by growth factors, which are likely to be latent. The scaffold, associated proteins, and bound growth factors, together with cellular receptors that can sense the microfibril matrix, constitute the fibrillin microenvironment. Activation of TGF beta signaling is associated with the Marfan syndrome, which is caused by mutations in fibrillin-1. Today we know that mutations in fibrillin-1 cause the Marfan syndrome as well as Weill-Marchesani syndrome (and other acromelic dysplasias) and result in opposite clinical phenotypes: tall or short stature; arachnodactyly or brachydactyly; joint hypermobility or stiff joints; hypomuscularity or hypermuscularity. We also know that these different syndromes are associated with different structural abnormalities in the fibrillin microfibril scaffold and perhaps with specific cellular receptors (mechanosensors). How does the microenvironment, framed by the microfibril scaffold and populated by latent growth factors, work? We must await future investigations for the molecular and cellular mechanisms that will answer this question. However, today we can appreciate the importance of the fibrillin microfibril niche as a contextual environment for growth factor signaling and potentially for mechanosensation. (C) 2015 Published by Elsevier B.V.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sengle, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Sakai, Lynn V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395720
DOI:	10.1016/j.matbio.2015.05.002
Journal or Publication Title:	Matrix Biol.
Volume:	47
Page Range:	S. 3 - 13
Date:	2015
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1569-1802
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LATENT TGF-BETA; BINDING-PROTEIN; EXTRACELLULAR-MATRIX; ANGIOTENSIN-II; AORTIC-ANEURYSMS; TYPE-1 RECEPTOR; CELL-ADHESION; MOUSE MODEL; IN-VIVO; MUTATIONS Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39572