Eduati, Federica
ORCID: 0000-0002-7822-3867, Mangravite, Lara M., Wang, Tao, Tang, Hao, Bare, J. Christopher
ORCID: 0000-0003-1006-1491, Huang, Ruili, Norman, Thea, Kellen, Mike, Menden, Michael P., Yang, Jichen, Zhan, Xiaowei, Zhong, Rui, Xiao, Guanghua, Xia, Menghang, Abdo, Nour, Kosyk, Oksana, Friend, Stephen, Dearry, Allen, Simeonov, Anton, Tice, Raymond R., Rusyn, Ivan
ORCID: 0000-0001-9340-7384, Wright, Fred A., Stolovitzky, Gustavo, Xie, Yang, Saez-Rodriguez, Julio
ORCID: 0000-0002-8552-8976, Aittokallio, Tero
ORCID: 0000-0002-0886-9769, Alaimo, Salvatore, Amadoz, Alicia
ORCID: 0000-0003-3915-0404, Ammad-ud-din, Muhammad, Azencott, Chloe-Agathe
ORCID: 0000-0003-1003-301X, Bacardit, Jaume
ORCID: 0000-0002-2692-7205, Barron, Pelham, Bernard, Elsa
ORCID: 0000-0002-2057-7187, Beyer, Andreas
ORCID: 0000-0002-3891-2123, Bin, Shao, van Boemmel, Alena, Borgwardt, Karsten, Brys, April M., Caffrey, Brian, Chang, Jeffrey, Chang, Jungsoo, Chheda, Himanshu, Christodoulou, Eleni G., Clement-Ziza, Mathieu
ORCID: 0000-0003-2763-249X, Cohen, Trevor, Cowherd, Marianne
ORCID: 0000-0002-3165-4504, Demeyer, Sofie
ORCID: 0000-0002-8193-5734, Dopazo, Joaquin, Elhard, Joel D., Falcao, Andre O.
ORCID: 0000-0002-3588-8746, Ferro, Alfredo, Friedenberg, David A., Giugno, Rosalba
ORCID: 0000-0001-9843-7638, Gong, Yunguo, Gorospe, Jenni W., Granville, Courtney A., Grimm, Dominik, Heinig, Matthias
ORCID: 0000-0002-5612-1720, Hernansaiz, Rosa D., Hintsanen, Petteri, Hochreiter, Sepp
ORCID: 0000-0001-7449-2528, Huang, Liang-Chin, Huska, Matthew, Jaiswal, Alok, Jiao, Yunlong, Kaski, Samuel
ORCID: 0000-0003-1925-9154, Kaur, Ismeet, Khan, Suleiman Ali, Klambauer, Guenter, Krasnogor, Natalio, Kuhn, Michael, Kursa, Miron Bartosz, Kutum, Rintu, Lazzarini, Nicola, Lee, Inhan, Leung, Michael K. K., Lim, Weng Khong
ORCID: 0000-0003-4391-1130, Liu, Charlie, Lopez, Felipe Llinares, Mammana, Alessandro, Mayr, Andreas, Michoel, Tom
ORCID: 0000-0003-4749-4725, Mongiovi, Misael, Moore, Jonathan D., Mpindi, John-Patrick, Narasimhan, Ravi, Opiyo, Stephen O., Pandey, Gaurav, Peabody, Andrea L., Perner, Juliane, Poso, Antti
ORCID: 0000-0003-4196-4204, Pulvirenti, Alfredo
ORCID: 0000-0002-9764-0295, Rawlik, Konrad, Reinhardt, Susanne, Riffle, Carol G., Ruderfer, Douglas, Sander, Aaron J., Savage, Richard S., Scornet, Erwan, Sebastian-Leon, Patricia, Sharan, Roded, Simon-Gabriel, Carl Johann, Stoven, Veronique, Sun, Jingchun, Tang, Jing
ORCID: 0000-0001-7480-7710, Teixeira, Ana L., Tenesa, Albert, Vert, Jean-Philippe
ORCID: 0000-0001-9510-8441, Vingron, Martin, Walter, Thomas
ORCID: 0000-0001-7419-7879, Wennerberg, Krister, Whalen, Sean, Wisniewska, Zofia, Wu, Yonghui, Xu, Hua, Zhang, Shihua, Zhao, Junfei and Zheng, W. Jim
(2015).
Prediction of human population responses to toxic compounds by a collaborative competition.
Nat. Biotechnol., 33 (9).
S. 933 - 944.
NEW YORK:
NATURE PUBLISHING GROUP.
ISSN 1546-1696
Full text not available from this repository.
Abstract
The ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing. Here, we report the results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations. We measured the cytotoxicity of 156 compounds in 884 lymphoblastoid cell lines for which genotype and transcriptional data are available as part of the Tox21 1000 Genomes Project. The challenge participants developed algorithms to predict interindividual variability of toxic response from genomic profiles and population-level cytotoxicity data from structural attributes of the compounds. 179 submitted predictions were evaluated against an experimental data set to which participants were blinded. Individual cytotoxicity predictions were better than random, with modest correlations (Pearson's r < 0.28), consistent with complex trait genomic prediction. In contrast, predictions of population-level response to different compounds were higher (r < 0.66). The results highlight the possibility of predicting health risks associated with unknown compounds, although risk estimation accuracy remains suboptimal.
Item Type: |
Journal Article
|
Creators: |
Creators | Email | ORCID | ORCID Put Code |
---|
Eduati, Federica | UNSPECIFIED | orcid.org/0000-0002-7822-3867 | UNSPECIFIED | Mangravite, Lara M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Tao | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tang, Hao | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bare, J. Christopher | UNSPECIFIED | orcid.org/0000-0003-1006-1491 | UNSPECIFIED | Huang, Ruili | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Norman, Thea | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kellen, Mike | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Menden, Michael P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yang, Jichen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zhan, Xiaowei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zhong, Rui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Xiao, Guanghua | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Xia, Menghang | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Abdo, Nour | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kosyk, Oksana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Friend, Stephen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dearry, Allen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Simeonov, Anton | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tice, Raymond R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rusyn, Ivan | UNSPECIFIED | orcid.org/0000-0001-9340-7384 | UNSPECIFIED | Wright, Fred A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stolovitzky, Gustavo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Xie, Yang | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Saez-Rodriguez, Julio | UNSPECIFIED | orcid.org/0000-0002-8552-8976 | UNSPECIFIED | Aittokallio, Tero | UNSPECIFIED | orcid.org/0000-0002-0886-9769 | UNSPECIFIED | Alaimo, Salvatore | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Amadoz, Alicia | UNSPECIFIED | orcid.org/0000-0003-3915-0404 | UNSPECIFIED | Ammad-ud-din, Muhammad | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Azencott, Chloe-Agathe | UNSPECIFIED | orcid.org/0000-0003-1003-301X | UNSPECIFIED | Bacardit, Jaume | UNSPECIFIED | orcid.org/0000-0002-2692-7205 | UNSPECIFIED | Barron, Pelham | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bernard, Elsa | UNSPECIFIED | orcid.org/0000-0002-2057-7187 | UNSPECIFIED | Beyer, Andreas | UNSPECIFIED | orcid.org/0000-0002-3891-2123 | UNSPECIFIED | Bin, Shao | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van Boemmel, Alena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Borgwardt, Karsten | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brys, April M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Caffrey, Brian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang, Jeffrey | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang, Jungsoo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chheda, Himanshu | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Christodoulou, Eleni G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Clement-Ziza, Mathieu | UNSPECIFIED | orcid.org/0000-0003-2763-249X | UNSPECIFIED | Cohen, Trevor | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cowherd, Marianne | UNSPECIFIED | orcid.org/0000-0002-3165-4504 | UNSPECIFIED | Demeyer, Sofie | UNSPECIFIED | orcid.org/0000-0002-8193-5734 | UNSPECIFIED | Dopazo, Joaquin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Elhard, Joel D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Falcao, Andre O. | UNSPECIFIED | orcid.org/0000-0002-3588-8746 | UNSPECIFIED | Ferro, Alfredo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Friedenberg, David A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giugno, Rosalba | UNSPECIFIED | orcid.org/0000-0001-9843-7638 | UNSPECIFIED | Gong, Yunguo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gorospe, Jenni W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Granville, Courtney A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Grimm, Dominik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Heinig, Matthias | UNSPECIFIED | orcid.org/0000-0002-5612-1720 | UNSPECIFIED | Hernansaiz, Rosa D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hintsanen, Petteri | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hochreiter, Sepp | UNSPECIFIED | orcid.org/0000-0001-7449-2528 | UNSPECIFIED | Huang, Liang-Chin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Huska, Matthew | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jaiswal, Alok | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jiao, Yunlong | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kaski, Samuel | UNSPECIFIED | orcid.org/0000-0003-1925-9154 | UNSPECIFIED | Kaur, Ismeet | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Khan, Suleiman Ali | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Klambauer, Guenter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Krasnogor, Natalio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kuhn, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kursa, Miron Bartosz | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kutum, Rintu | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lazzarini, Nicola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lee, Inhan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Leung, Michael K. K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lim, Weng Khong | UNSPECIFIED | orcid.org/0000-0003-4391-1130 | UNSPECIFIED | Liu, Charlie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lopez, Felipe Llinares | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mammana, Alessandro | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mayr, Andreas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Michoel, Tom | UNSPECIFIED | orcid.org/0000-0003-4749-4725 | UNSPECIFIED | Mongiovi, Misael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Moore, Jonathan D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mpindi, John-Patrick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Narasimhan, Ravi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Opiyo, Stephen O. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pandey, Gaurav | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peabody, Andrea L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Perner, Juliane | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Poso, Antti | UNSPECIFIED | orcid.org/0000-0003-4196-4204 | UNSPECIFIED | Pulvirenti, Alfredo | UNSPECIFIED | orcid.org/0000-0002-9764-0295 | UNSPECIFIED | Rawlik, Konrad | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Reinhardt, Susanne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Riffle, Carol G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ruderfer, Douglas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sander, Aaron J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Savage, Richard S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Scornet, Erwan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sebastian-Leon, Patricia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sharan, Roded | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Simon-Gabriel, Carl Johann | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stoven, Veronique | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sun, Jingchun | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tang, Jing | UNSPECIFIED | orcid.org/0000-0001-7480-7710 | UNSPECIFIED | Teixeira, Ana L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tenesa, Albert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vert, Jean-Philippe | UNSPECIFIED | orcid.org/0000-0001-9510-8441 | UNSPECIFIED | Vingron, Martin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Walter, Thomas | UNSPECIFIED | orcid.org/0000-0001-7419-7879 | UNSPECIFIED | Wennerberg, Krister | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Whalen, Sean | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wisniewska, Zofia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wu, Yonghui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Xu, Hua | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zhang, Shihua | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zhao, Junfei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zheng, W. Jim | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
|
URN: |
urn:nbn:de:hbz:38-395767 |
DOI: |
10.1038/nbt.3299 |
Journal or Publication Title: |
Nat. Biotechnol. |
Volume: |
33 |
Number: |
9 |
Page Range: |
S. 933 - 944 |
Date: |
2015 |
Publisher: |
NATURE PUBLISHING GROUP |
Place of Publication: |
NEW YORK |
ISSN: |
1546-1696 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
GENOME-WIDE ASSOCIATION; EXPRESSION; SENSITIVITY; KNOWLEDGE; LIBRARY; MODEL; SET | Multiple languages | Biotechnology & Applied Microbiology | Multiple languages |
|
URI: |
http://kups.ub.uni-koeln.de/id/eprint/39576 |
Downloads per month over past year
Export