Universität zu Köln

Ermolaeva, Maria A., Dakhovnik, Alexander and Schumacher, Bjoern (2015). Quality control mechanisms in cellular and systemic DNA damage responses. Ageing Res. Rev., 23. S. 3 - 12. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-9649

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Abstract

The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage is thought to contribute to the functional decline of tissues and organs with ageing. Defects in multiple genome maintenance systems cause human disorders characterized by cancer susceptibility, developmental failure, and premature ageing. The complex pathological consequences of genome instability are insufficiently explained by cell-autonomous DNA damage responses (DDR) alone. Quality control pathways play an important role in DNA repair and cellular DDR pathways. Recent years have revealed non-cell autonomous effects of DNA damage that impact the physiological adaptations during ageing. We will discuss the role of quality assurance pathways in cell-autonomous and systemic responses to genome instability. (C) 2015 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ermolaeva, Maria A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dakhovnik, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-396005
DOI:	10.1016/j.arr.2014.12.009
Journal or Publication Title:	Ageing Res. Rev.
Volume:	23
Page Range:	S. 3 - 12
Date:	2015
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-9649
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEOTIDE EXCISION-REPAIR; RNA-POLYMERASE-II; STRAND BREAK REPAIR; C. ELEGANS HOMOLOG; FANCONI-ANEMIA; INDUCED UBIQUITINATION; PROTEIN; TRANSCRIPTION; PCNA; P53 Multiple languages Cell Biology; Geriatrics & Gerontology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39600