Universität zu Köln

Shaabani, Namir, Honke, Nadine, Dolff, Sebastian ORCID: 0000-0001-5549-1706, Goerg, Boris, Khairnar, Vishal ORCID: 0000-0002-3584-7530, Merches, Katja, Duhan, Vikas ORCID: 0000-0002-6337-8225, Metzger, Sabine, Recher, Mike ORCID: 0000-0002-9121-6936, Barthuber, Carmen, Hardt, Cornelia, Proksch, Peter, Haeussinger, Dieter, Witzke, Oliver, Lang, Philipp A. and Lang, Karl S. (2015). IFN-gamma licenses CD11b(+) cells to induce progression of systemic lupus erythematosus. J. Autoimmun., 62. S. 11 - 22. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1095-9157

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Abstract

Autoantibodies are a hallmark of autoimmune diseases, such as rheumatoid arthritis, autoimmune hepatitis, and systemic lupus erythematosus (SLE). High titers of anti-nuclear antibodies are used as surrogate marker for SLE, however their contribution to pathogenesis remains unclear. Using murine model of SLE and human samples, we studied the effect of immune stimulation on relapsing of SLE. Although autoantibodies bound to target cells in vivo, only additional activation of CD8(+) T cells converted this silent autoimmunity into overt disease. In mice as well as in humans CU8(+) T cells derived IFN-gamma enhanced expression of Fc-receptors on CD11b(+) cells. High expression of Fc-receptors allowed CD11b(+) cells to bind to antibody covered target cells and to destroy them in vivo. We found that autoantibodies induce clinically relevant disease when adaptive immunity, specific for disease non-related antigen, is activated. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shaabani, Namir UNSPECIFIED UNSPECIFIED UNSPECIFIED Honke, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolff, Sebastian UNSPECIFIED orcid.org/0000-0001-5549-1706 UNSPECIFIED Goerg, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Khairnar, Vishal UNSPECIFIED orcid.org/0000-0002-3584-7530 UNSPECIFIED Merches, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Duhan, Vikas UNSPECIFIED orcid.org/0000-0002-6337-8225 UNSPECIFIED Metzger, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Recher, Mike UNSPECIFIED orcid.org/0000-0002-9121-6936 UNSPECIFIED Barthuber, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardt, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Proksch, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeussinger, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Witzke, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Philipp A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Karl S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397391
DOI:	10.1016/j.jaut.2015.05.007
Journal or Publication Title:	J. Autoimmun.
Volume:	62
Page Range:	S. 11 - 22
Date:	2015
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1095-9157
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPHOCYTIC CHORIOMENINGITIS VIRUS; AUTOIMMUNE-DISEASE; INTERFERON-GAMMA; RECEPTOR EXPRESSION; MEMORY-PHENOTYPE; T-CELLS; IN-VIVO; AUTOANTIBODIES; NEUTROPHILS; MECHANISMS Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39739