Universität zu Köln

Wolf, Peter, Targas Yacubian, Elza Marcia, Avanzini, Giuliano, Sander, Thomas, Schmitz, Bettina, Wandschneider, Britta and Koepp, Matthias (2015). Juvenile myoclonic epilepsy: A system disorder of the brain. Epilepsy Res., 114. S. 2 - 13. AMSTERDAM: ELSEVIER. ISSN 1872-6844

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Abstract

The prevailing understanding of generalized epilepsy is shaped by the traditional definition that the responsible neuronal discharge takes place, if not throughout the entire grey matter, then at least in the greater part of it and simultaneously on both sides. This view is no longer tenable since concurrent findings using multiple methods have accumulated to reveal the role of bilateral networks of distributed and selective cortical and subcortical structures in so-called generalized ictogenesis. Most of this research has been focused on juvenile myoclonic epilepsy (JME), which today is commonly considered the archetypical syndrome of the idiopathic generalized epilepsies. Based upon recent research in the fields of clinical epileptology, neuropsychology and psychiatry, clinical neurophysiology, neuroimaging and epilepsy genetics this article, for the first time, unites these new findings into a comprehensive nosological view. Genetically determined dysfunctions of important cognitive systems like visuomotor coordination and linguistic communication appear now as key mechanisms of seizure generation in JME. This review suggests a new paradigm to consider JME as a system disorder of the brain analogous to other neurological system disorders. (C) 2015 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wolf, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Targas Yacubian, Elza Marcia UNSPECIFIED UNSPECIFIED UNSPECIFIED Avanzini, Giuliano UNSPECIFIED UNSPECIFIED UNSPECIFIED Sander, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wandschneider, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Koepp, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-398037
DOI:	10.1016/j.eplepsyres.2015.04.008
Journal or Publication Title:	Epilepsy Res.
Volume:	114
Page Range:	S. 2 - 13
Date:	2015
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1872-6844
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IDIOPATHIC GENERALIZED EPILEPSIES; PSYCHIATRIC COMORBIDITY; COGNITIVE DYSFUNCTION; CORTICAL THICKNESS; PERSONALITY-TRAITS; EYELID MYOCLONIA; WAVE DISCHARGES; FMRI ACTIVATION; INCREASE RISK; EEG Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39803