Universität zu Köln

Weiss, Peter H. ORCID: 0000-0002-5230-9080, Herzog, Jan, Poetter-Nerger, Monika, Falk, Daniela, Herzog, Hans, Deuschl, Guenther, Volkmann, Jens ORCID: 0000-0002-9570-593X and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2015). Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers. Mov. Disord., 30 (8). S. 1121 - 1126. HOBOKEN: WILEY-BLACKWELL. ISSN 1531-8257

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Abstract

BackgroundSubthalamic deep brain stimulation (STN-DBS) can ameliorate gait disturbances in Parkinson's disease (PD). Using motor imagery and positron emission tomography (PET), we investigated how STN-DBS interacts with supraspinal locomotor centers in PD. MethodsTen PD patients with bilateral STN-DBS actually walked or stood still under STN-DBS ON or OFF conditions. Directly thereafter, subjects imagined walking or standing while changes in regional cerebral blood flow were measured by PET. ResultsIndependent of STN-DBS, imagined walking distance correlated with imagery duration. Compared with STN-DBS OFF, STN-DBS ON improved actual gait and increased imagined walking distance. Imagery of gait (vs. stance) induced activity in the supplementary motor area and the right superior parietal lobule for both STN-DBS conditions. The improvement of imagined gait during STN-DBS ON led to activity changes in the pedunculopontine nucleus/mesencephalic locomotor region (PPN/MLR). ConclusionsData suggest that STN-DBS improves Parkinsonian gait by modulating PPN/MLR activity. (c) 2015 International Parkinson and Movement Disorder Society

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED Herzog, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Poetter-Nerger, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Falk, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Herzog, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Deuschl, Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Volkmann, Jens UNSPECIFIED orcid.org/0000-0002-9570-593X UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-400511
DOI:	10.1002/mds.26229
Journal or Publication Title:	Mov. Disord.
Volume:	30
Number:	8
Page Range:	S. 1121 - 1126
Date:	2015
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOTOR IMAGERY; URINARY-BLADDER; DISEASE; DISTURBANCES; IMPAIRMENT; ACTIVATION; NETWORK; PET Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40051