Morfeld, P. and Spallek, M. (2015). Risk assessment given exposure to several carcinogenic substances. Zentralblatt Arb. Arb. Ergon., 65 (4). S. 192 - 203. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2198-0713
Full text not available from this repository.Abstract
In order to perform risk assessment for exposure to multiple (carcinogenic) substances at workplaces, simple summation formulae were proposed and are still being proposed, with which a common effect of different occupational exposures should be mapped to the same cancer endpoint. However, this approach is not applicable for methodological reasons. Even if preventive and synergistic effects can be excluded, it does not follow that single excess risks can be added in simplified terms. A lower bound of the joint excess risk is the maximum of the single excess risks if no preventive action exists. If synergy can be additionally excluded, an upper bound is given by the sum of the single excess risks; this means that exposures with thresholds can be efficiently controlled by compliance with the single limits. A summation index as defined in the German activities with carcinogenic substances (TRGS) 402 cannot be justified in this situation, especially not for carcinogenic substances with a workplace threshold value. In the case of a superadditivity of excess risks of two substances, the single substances do not both have to be strictly controlled because the control of one substance will already lead to a substantial risk reduction. Furthermore, more precise estimates need data from controlled targeted experiments or epidemiological studies which directly investigate the combined action of the exposure components.
| Item Type: | Journal Article | ||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-400683 | ||||||||||||
| DOI: | 10.1007/s40664-015-0032-1 | ||||||||||||
| Journal or Publication Title: | Zentralblatt Arb. Arb. Ergon. | ||||||||||||
| Volume: | 65 | ||||||||||||
| Number: | 4 | ||||||||||||
| Page Range: | S. 192 - 203 | ||||||||||||
| Date: | 2015 | ||||||||||||
| Publisher: | SPRINGER HEIDELBERG | ||||||||||||
| Place of Publication: | HEIDELBERG | ||||||||||||
| ISSN: | 2198-0713 | ||||||||||||
| Language: | German | ||||||||||||
| Faculty: | Unspecified | ||||||||||||
| Divisions: | Unspecified | ||||||||||||
| Subjects: | no entry | ||||||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/40068 |
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