Universität zu Köln

Tsagoudis, K. and Ostendorf, R. (2015). Modern Management of Thrombosis. Aktuel. Dermatol., 41 (6). S. 225 - 234. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-938X

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Abstract

The combination of D-dimer test and clinical signs of the Wells rule is sufficient to exclude deep-vein thrombosis in non-oncological patients, as again proved by a large meta-analysis. In these cases, time-consuming duplex ultrasonography is unnecessary. After being controversially discussed 15-20 years ago, outpatient treatment meanwhile is favoured in approximately 95% of the cases. Since development of ultrasound scanners is improving steadily, venography is losing its significance as a reference-tool in the diagnosis of deep-vein thrombosis. In recent years the approval of three oral anticoagulants rivaroxaban, apixaban and dabigatran (after day 5) in addition to the established agents fondaparinux, phenprocoumon, warfarin, low-molecular-weight heparin and unfractionated heparin has changed outpatient treatment of deep-vein thrombosis. Several new anticoagulants will follow, their significance in daily routine and the value of their different dose schemes during the treatment-period will have to be defined yet. Individual aspects are becoming more and more important in deciding on the treatment option. Effective compression therapy of the lower limb remains essential after deep-vein thrombosis, even though a recent clinical study could not illustrate its effect.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tsagoudis, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostendorf, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-402248
DOI:	10.1055/s-0034-1391974
Journal or Publication Title:	Aktuel. Dermatol.
Volume:	41
Number:	6
Page Range:	S. 225 - 234
Date:	2015
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-938X
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ORAL ANTICOAGULANTS; VENOUS THROMBOEMBOLISM; D-DIMER; DABIGATRAN; FONDAPARINUX; PHARMACOLOGY; INHIBITOR; APIXABAN; WARFARIN; PHARMACODYNAMICS Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40224