Universität zu Köln

Konradi, J., Mollenhauer, M., Baldus, S. and Klinke, A. (2015). Redox-sensitive mechanisms underlying vascular dysfunction in heart failure. Free Radic. Res., 49 (6). S. 721 - 743. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2470

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Abstract

Regardless of the progress in therapeutic drugs and devices to treat heart failure (HF) during the last few years, the clinical outcome of this disease remains deleterious. Impaired left ventricular function leads to neurohumoral activation, altered local shear forces, and hypoxia, which might give rise to inflammatory processes within the vasculature. Among those, the imbalance of the redox equilibrium toward increased concentrations of reactive oxygen species (ROS) is particularly important, as it affects the integrity of vascular function. Apart from injured or dysfunctional cardiomyocytes, vascular dysfunction has been demonstrated to play a crucial role in the development and progression of HF, which makes it an interesting target for new HF therapies. The mechanisms that initiate vascular dysfunction in HF pathogenesis and the processes leading to oxidative stress are not yet fully elucidated. However, oxidative stress promotes a variety of redox-sensitive mechanisms contributing to vascular dysfunction in HF. Here, we will summarize the sources of ROS in the vasculature, elucidate the impact of oxidative stress on functional and structural vascular remodeling, and consider the link to vascular dysfunction. Furthermore, we will point out the importance of vascular dysfunction in HF and discuss therapeutic options.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Konradi, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollenhauer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klinke, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-402310
DOI:	10.3109/10715762.2015.1027200
Journal or Publication Title:	Free Radic. Res.
Volume:	49
Number:	6
Page Range:	S. 721 - 743
Date:	2015
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1029-2470
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS; NEUTRAL ENDOPEPTIDASE INHIBITION; NECROSIS-FACTOR-ALPHA; ENDOTHELIN-1 GENE-EXPRESSION; OXYGEN SPECIES PRODUCTION; CORONARY-ARTERY-DISEASE; ANGIOTENSIN-II; NADPH OXIDASE; OXIDATIVE STRESS Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40231