Universität zu Köln

Kroner, Juliana de Castro, Sommer, Andrea and Fabri, Mario (2015). Vitamin D Every Day to Keep the Infection Away? Nutrients, 7 (6). S. 4170 - 4189. BASEL: MDPI. ISSN 2072-6643

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Abstract

Within the last decade, vitamin D has emerged as a central regulator of host defense against infections. In this regard, vitamin D triggers effective antimicrobial pathways against bacterial, fungal and viral pathogens in cells of the human innate immune system. However, vitamin D also mediates potent tolerogenic effects: it is generally believed that vitamin D attenuates inflammation and acquired immunity, and thus potentially limits collateral tissue damage. Nevertheless, several studies indicate that vitamin D promotes aspects of acquired host defense. Clinically, vitamin D deficiency has been associated with an increased risk for various infectious diseases in epidemiological studies; yet, robust data from controlled trials investigating the use of vitamin D as a preventive or therapeutic agent are missing. In this review, we summarize the current knowledge regarding the effect of vitamin D on innate and acquired host defense, and speculate on the difficulties to translate the available molecular medicine data into practical therapeutic or preventive recommendations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kroner, Juliana de Castro UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommer, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Fabri, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-402360
DOI:	10.3390/nu7064170
Journal or Publication Title:	Nutrients
Volume:	7
Number:	6
Page Range:	S. 4170 - 4189
Date:	2015
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6643
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CATHELICIDIN ANTIMICROBIAL PEPTIDE; REGULATORY T-CELLS; 1,25-DIHYDROXYVITAMIN D-3; D-RECEPTOR; DENDRITIC CELLS; MYCOBACTERIUM-TUBERCULOSIS; 1-ALPHA,25-DIHYDROXYVITAMIN D-3; 25-HYDROXYVITAMIN D-3; ANTIGEN PRESENTATION; CYTOKINE PRODUCTION Multiple languages Nutrition & Dietetics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40236