Universität zu Köln

Schwarz, A., Pick, C., Harrach, R., Stein, G., Bendella, H., Ozsoy, O., Ozsoy, U., Schoenau, E., Jaminet, P., Sarikcioglu, L., Dunlop, S. and Angelov, D. N. (2015). Reactions of the rat musculoskeletal system to compressive spinal cord injury (SCI) and whole body vibration (WBV) therapy. J. Musculoskelet. Neuronal Interact., 15 (2). S. 123 - 137. NAFPLION: JMNI. ISSN 1108-7161

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Abstract

Traumatic spinal cord injury (SCI) causes a loss of locomotor function with associated compromise of the musculo-skeletal system. Whole body vibration (WBV) is a potential therapy following SCI, but little is known about its effects on the musculo-skeletal system. Here, we examined locomotor recovery and the musculo-skeletal system after thoracic (T7-9) compression SCI in adult rats. Daily WBV was started at 1, 7, 14 and 28 days after injury (WBV1-WBV28 respectively) and continued over a 12-week post-injury period. Intact rats, rats with SCI but no WBV (sham-treated) and a group that received passive flexion and extension (PFE) of their hind limbs served as controls. Compared to sham-treated rats, neither WBV nor PFE improved motor function. Only WBV14 and PFE improved body support. In line with earlier studies we failed to detect signs of soleus muscle atrophy (weight, cross sectional diameter, total amount of fibers, mean fiber diameter) or bone loss in the femur (length, weight, bone mineral density). One possible explanation is that, despite of injury extent, the preservation of some axons in the white matter, in combination with quadripedal locomotion, may provide sufficient trophic and neuronal support for the musculoskeletal system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwarz, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pick, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Harrach, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ozsoy, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ozsoy, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaminet, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarikcioglu, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunlop, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, D. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-402716
Journal or Publication Title:	J. Musculoskelet. Neuronal Interact.
Volume:	15
Number:	2
Page Range:	S. 123 - 137
Date:	2015
Publisher:	JMNI
Place of Publication:	NAFPLION
ISSN:	1108-7161
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE-MINERAL DENSITY; SKELETAL-MUSCLE; HINDLIMB IMMOBILIZATION; FUNCTIONAL RECOVERY; LOCOMOTOR FUNCTION; CONTUSION; MODEL; ADAPTATIONS; PREVENTION; STRENGTH Multiple languages Neurosciences; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40271