Martinez-Martin, Pablo ORCID: 0000-0003-0837-5280, Reddy, Prashanth, Katzenschlager, Regina, Antonini, Angelo ORCID: 0000-0003-1040-2807, Todorova, Antoniya, Odin, Per, Henriksen, Tove, Martin, Anne, Calandrella, Daniela ORCID: 0000-0002-4803-0490, Rizos, Alexandra, Bryndum, Narissah, Glad, Arne, Dafsari, Haidar Salimi, Timmermann, Lars, Ebersbach, Georg ORCID: 0000-0003-3403-6987, Kramberger, Milica G., Samuel, Michael, Wenzel, Karoline, Tomantschger, Volker, Storch, Alexander, Reichmann, Heinz, Pirtosek, Zvezdan ORCID: 0000-0002-5495-944X, Trost, Maja, Svenningsson, Per, Palhagen, Sven, Volkmann, Jens ORCID: 0000-0002-9570-593X and Chaudhuri, K. Ray (2015). EuroInf: A Multicenter Comparative Observational Study of Apomorphine and Levodopa Infusion in Parkinson's Disease. Mov. Disord., 30 (4). S. 510 - 517. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Subcutaneous apomorphine infusion (Apo) and intrajejunal levodopa infusion (IJLI) are two treatment options for patients with advanced Parkinson's disease (PD) and refractory motor complications, with varying cost of treatment. There are no multicenter studies comparing the effects of the two strategies. This open-label, prospective, observational, 6-month, multicenter study compared 43 patients on Apo (48.8% males, age 62.3 +/- 10.6 years; disease duration: 14 +/- 4.4 years; median H & Y stage 3; interquartile range [IQR]: 3-4) and 44 on IJLI (56.8% males, age 62.7 +/- 9.1 years; disease duration: 16.1 +/- 6.7 years; median H & Y stage 4; IQR, 3-4). Cohen's effect sizes (0.8 considered as large) were large with both therapies with respect to total motor, nonmotor, and quality-of-life scores. The Non-Motor Symptoms Scale (NMSS) with Apo showed moderate improvement, whereas sleep/fatigue, gastrointestinal, urinary, and sexual dimensions of the NMSS showed significantly higher improvement with IJLI. Seventy-five percent on IJLI improved in their quality-of-life and nonmotor symptoms (NMS), whereas in the Apo group, a similar proportion improved in quality of life, but 40% in NMS. Adverse effects included peritonitis with IJLI and skin nodules on Apo. Based on this open-label, nonrandomized, comparative study, we report that, in advanced Parkinson's patients, both IJLI and Apo infusion therapy appear to provide a robust improvement in motor symptoms, motor complications, quality-of-life, and some NMS. Controlled, randomized studies are required. (c) 2014 International Parkinson and Movement Disorder Society

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Martinez-Martin, PabloUNSPECIFIEDorcid.org/0000-0003-0837-5280UNSPECIFIED
Reddy, PrashanthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katzenschlager, ReginaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonini, AngeloUNSPECIFIEDorcid.org/0000-0003-1040-2807UNSPECIFIED
Todorova, AntoniyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Odin, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henriksen, ToveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calandrella, DanielaUNSPECIFIEDorcid.org/0000-0002-4803-0490UNSPECIFIED
Rizos, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bryndum, NarissahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glad, ArneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dafsari, Haidar SalimiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ebersbach, GeorgUNSPECIFIEDorcid.org/0000-0003-3403-6987UNSPECIFIED
Kramberger, Milica G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samuel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wenzel, KarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomantschger, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reichmann, HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pirtosek, ZvezdanUNSPECIFIEDorcid.org/0000-0002-5495-944XUNSPECIFIED
Trost, MajaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Svenningsson, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palhagen, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volkmann, JensUNSPECIFIEDorcid.org/0000-0002-9570-593XUNSPECIFIED
Chaudhuri, K. RayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-403298
DOI: 10.1002/mds.26067
Journal or Publication Title: Mov. Disord.
Volume: 30
Number: 4
Page Range: S. 510 - 517
Date: 2015
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1531-8257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NONMOTOR SYMPTOMS SCALE; CONVENTIONAL THERAPY; INTESTINAL GEL; MOTOR; COMPLICATIONS; MANAGEMENT; NEUROPATHY; LIFEMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40329

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