Michailidou, Kyriaki ORCID: 0000-0001-7065-1237, Beesley, Jonathan ORCID: 0000-0003-1942-325X, Lindstrom, Sara, Canisius, Sander, Dennis, Joe, Lush, Michael J., Maranian, Mel J., Bolla, Manjeet K., Wang, Qin, Shah, Mitul, Perkins, Barbara J., Czene, Kamila, Eriksson, Mikael, Darabi, Hatef, Brand, Judith S. ORCID: 0000-0002-3720-1274, Bojesen, Stig E., Nordestgaard, Borge G., Flyger, Henrik, Nielsen, Sune F., Rahman, Nazneen ORCID: 0000-0003-4376-0440, Turnbull, Clare ORCID: 0000-0002-1734-5772, Fletcher, Olivia ORCID: 0000-0001-9387-7116, Peto, Julian, Gibson, Lorna, dos-Santos-Silva, Isabel, Chang-Claude, Jenny, Flesch-Janys, Dieter, Rudolph, Anja, Eilber, Ursula, Behrens, Sabine, Nevanlinna, Heli, Muranen, Taru A., Aittomaki, Kristiina, Blomqvist, Carl ORCID: 0000-0003-3041-1938, Khan, Sofia ORCID: 0000-0003-4185-8882, Aaltonen, Kirsimari, Ahsan, Habibul, Kibriya, Muhammad G., Whittemore, Alice S., John, Esther M., Malone, Kathleen E., Gammon, Marilie D., Santella, Regina M., Ursin, Giske ORCID: 0000-0002-0835-9507, Makalic, Enes, Schmidt, Daniel F., Casey, Graham, Hunter, David J., Gapstur, Susan M., Gaudet, Mia M., Diver, W. Ryan, Haiman, Christopher A., Schumacher, Fredrick ORCID: 0000-0002-3073-7463, Henderson, Brian E., Le Marchand, Loic, Berg, Christine D., Chanock, Stephen J., Figueroa, Jonine, Hoover, Robert N., Lambrechts, Diether ORCID: 0000-0002-3429-302X, Neven, Patrick, Wildiers, Hans, van Limbergen, Erik, Schmidt, Marjanka K., Broeks, Annegien, Verhoef, Senno, Cornelissen, Sten, Couch, Fergus J., Olson, Janet E., Hallberg, Emily, Vachon, Celine, Waisfisz, Quinten, Meijers-Heijboer, Hanne, Adank, Muriel A., van der Luijt, Rob B., Li, Jingmei ORCID: 0000-0001-8587-7511, Liu, Jianjun ORCID: 0000-0002-3255-3019, Humphreys, Keith, Kang, Daehee ORCID: 0000-0003-4031-5878, Choi, Ji-Yeob, Park, Sue K., Yoo, Keun-Young, Matsuo, Keitaro ORCID: 0000-0003-1761-6314, Ito, Hidemi ORCID: 0000-0002-8023-4581, Iwata, Hiroji, Tajima, Kazuo, Guenel, Pascal ORCID: 0000-0002-8359-518X, Truong, Therese ORCID: 0000-0002-2943-6786, Mulot, Claire, Sanchez, Marie, Burwinkel, Barbara, Marme, Frederik, Surowy, Harald ORCID: 0000-0002-3595-9188, Sohn, Christof, Wu, Anna H., Tseng, Chiu-chen, Van den Berg, David, Stram, Daniel O., Gonzalez-Neira, Anna, Benitez, Javier, Zamora, M. Pilar, Arias Perez, Jose Ignacio, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Cox, Angela ORCID: 0000-0002-5138-1099, Cross, Simon S., Reed, Malcolm W. R., Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Mulligan, Anna Marie ORCID: 0000-0002-7239-5297, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Lindblom, Annika, Margolin, Sara, Teo, Soo Hwang, Yip, Cheng Har, Taib, Nur Aishah Mohd ORCID: 0000-0001-8419-0478, Tan, Gie-Hooi, Hooning, Maartje J., Hollestelle, Antoinette ORCID: 0000-0003-1166-1966, Martens, John W. M., Collee, J. Margriet, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Hopper, John L., Southey, Melissa C., Tsimiklis, Helen, Apicella, Carmel, Shen, Chen-Yang, Hsiung, Chia-Ni, Wu, Pei-Ei, Hou, Ming-Feng ORCID: 0000-0001-6030-9702, Kristensen, Vessela N., Nord, Silje ORCID: 0000-0002-3271-5356, Alnaes, Grethe I. Grenaker, Giles, Graham G., Milne, Roger L., McLean, Catriona, Canzian, Federico ORCID: 0000-0002-4261-4583, Trichopoulos, Dimitrios, Peeters, Petra, Lund, Eiliv, Sund, Malin, Khaw, Kay-Tee, Gunter, Marc J., Palli, Domenico, Mortensen, Lotte Maxild, Dossus, Laure, Huerta, Jose-Maria, Meindl, Alfons, Schmutzler, Rita K., Sutter, Christian, Yang, Rongxi, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Hartman, Mikael ORCID: 0000-0001-5726-9965, Miao, Hui, Chia, Kee Seng, Chan, Ching Wan ORCID: 0000-0002-9250-1296, Fasching, Peter A., Hein, Alexander ORCID: 0000-0003-2601-3398, Beckmann, Matthias W., Haeberle, Lothar, Brenner, Hermann ORCID: 0000-0002-6129-1572, Dieffenbach, Aida Karina, Arndt, Volker ORCID: 0000-0001-9320-8684, Stegmaier, Christa, Ashworth, Alan, Orr, Nick, Schoemaker, Minouk J., Swerdlow, Anthony J., Brinton, Louise, Garcia-Closas, Montserrat ORCID: 0000-0003-1033-2650, Zheng, Wei ORCID: 0000-0003-1226-070X, Halverson, Sandra L., Shrubsole, Martha, Long, Jirong ORCID: 0000-0002-7433-9766, Goldberg, Mark S., Labreche, France, Dumont, Martine, Winqvist, Robert, Pylkas, Katri ORCID: 0000-0002-2449-0521, Jukkola-Vuorinen, Arja, Grip, Mervi, Brauch, Hiltrud ORCID: 0000-0001-7531-2736, Hamann, Ute, Bruening, Thomas, Radice, Paolo ORCID: 0000-0001-6298-4111, Peterlongo, Paolo ORCID: 0000-0001-6951-6855, Manoukian, Siranoush, Bernard, Loris, Bogdanova, Natalia V., Doerk, Thilo, Mannermaa, Arto, Kataja, Vesa ORCID: 0000-0003-4846-4843, Kosma, Veli-Matti, Hartikainen, Jaana M., Devilee, Peter ORCID: 0000-0002-8023-2009, Tollenaar, Robert A. E. M., Seynaeve, Caroline, Van Asperen, Christi J., Jakubowska, Anna ORCID: 0000-0002-5650-0501, Lubinski, Jan ORCID: 0000-0003-2931-3003, Jaworska, Katarzyna, Huzarski, Tomasz ORCID: 0000-0003-3857-4854, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Ambrosone, Christine B., Yannoukakos, Drakoulis ORCID: 0000-0001-7509-3510, Kabisch, Maria, Torres, Diana, Neuhausen, Susan L., Anton-Culver, Hoda, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Healey, Catherine S., Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Pita, Guillermo ORCID: 0000-0003-2393-0510, Rosario Alonso, M., Alvarez, Nuria, Herrero, Daniel, Simard, Jacques, Pharoah, Paul P. D. P., Kraft, Peter, Dunning, Alison M., Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Hall, Per and Easton, Douglas F.
(2015).
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Nature Genet., 47 (4).
S. 373 - 382.
NEW YORK:
NATURE PUBLISHING GROUP.
ISSN 1546-1718
Full text not available from this repository.
Abstract
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining similar to 14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 x 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.
Item Type: |
Journal Article
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Creators: |
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Michailidou, Kyriaki | UNSPECIFIED | orcid.org/0000-0001-7065-1237 | UNSPECIFIED | Beesley, Jonathan | UNSPECIFIED | orcid.org/0000-0003-1942-325X | UNSPECIFIED | Lindstrom, Sara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Canisius, Sander | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dennis, Joe | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lush, Michael J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Maranian, Mel J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bolla, Manjeet K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Qin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shah, Mitul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Perkins, Barbara J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Czene, Kamila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eriksson, Mikael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Darabi, Hatef | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brand, Judith S. | UNSPECIFIED | orcid.org/0000-0002-3720-1274 | UNSPECIFIED | Bojesen, Stig E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nordestgaard, Borge G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Flyger, Henrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nielsen, Sune F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rahman, Nazneen | UNSPECIFIED | orcid.org/0000-0003-4376-0440 | UNSPECIFIED | Turnbull, Clare | UNSPECIFIED | orcid.org/0000-0002-1734-5772 | UNSPECIFIED | Fletcher, Olivia | UNSPECIFIED | orcid.org/0000-0001-9387-7116 | UNSPECIFIED | Peto, Julian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gibson, Lorna | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | dos-Santos-Silva, Isabel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang-Claude, Jenny | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Flesch-Janys, Dieter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rudolph, Anja | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eilber, Ursula | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Behrens, Sabine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nevanlinna, Heli | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muranen, Taru A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Aittomaki, Kristiina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Blomqvist, Carl | UNSPECIFIED | orcid.org/0000-0003-3041-1938 | UNSPECIFIED | Khan, Sofia | UNSPECIFIED | orcid.org/0000-0003-4185-8882 | UNSPECIFIED | Aaltonen, Kirsimari | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ahsan, Habibul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kibriya, Muhammad G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Whittemore, Alice S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | John, Esther M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Malone, Kathleen E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gammon, Marilie D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Santella, Regina M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ursin, Giske | UNSPECIFIED | orcid.org/0000-0002-0835-9507 | UNSPECIFIED | Makalic, Enes | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmidt, Daniel F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Casey, Graham | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hunter, David J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gapstur, Susan M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gaudet, Mia M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Diver, W. 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D. P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kraft, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dunning, Alison M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chenevix-Trench, Georgia | UNSPECIFIED | orcid.org/0000-0002-1878-2587 | UNSPECIFIED | Hall, Per | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Easton, Douglas F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
|
URN: |
urn:nbn:de:hbz:38-404361 |
DOI: |
10.1038/ng.3242 |
Journal or Publication Title: |
Nature Genet. |
Volume: |
47 |
Number: |
4 |
Page Range: |
S. 373 - 382 |
Date: |
2015 |
Publisher: |
NATURE PUBLISHING GROUP |
Place of Publication: |
NEW YORK |
ISSN: |
1546-1718 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
CONFER SUSCEPTIBILITY; GENOTYPE IMPUTATION; COMMON VARIANTS; OVARIAN-CANCER; RISK; ESTROGEN; CHEK2-ASTERISK-1100DELC; METAANALYSIS; ALLELES; BRCA1 | Multiple languages | Genetics & Heredity | Multiple languages |
|
URI: |
http://kups.ub.uni-koeln.de/id/eprint/40436 |
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