Universität zu Köln

Stephan, Alexander and Fabri, Mario (2015). The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity. Exp. Dermatol., 24 (3). S. 161 - 167. HOBOKEN: WILEY. ISSN 1600-0625

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Abstract

Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self- and non-self-stimuli. It has become clear that NETs are potent triggers of inflammation in autoimmune skin diseases. Moreover, the ability of NETs to trap pathogens suggests a crucial role in innate host defense. However, the outcome of the encounter between pathogens and NETs remains highly controversial. Here, we discuss recent insights into the morphology and formation of NETs, their role in skin inflammation and how NETs might contribute to host protection in skin infection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stephan, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Fabri, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-405567
DOI:	10.1111/exd.12599
Journal or Publication Title:	Exp. Dermatol.
Volume:	24
Number:	3
Page Range:	S. 161 - 167
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0625
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYSTEMIC-LUPUS-ERYTHEMATOSUS; GROUP-A STREPTOCOCCUS; CELL-DEATH; NETTING NEUTROPHILS; NADPH OXIDASE; IN-VIVO; RELEASE; MYELOPEROXIDASE; DNA; NETOSIS Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40556